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• W4253364891 abstract "Background and Objectives: Neonatal alloimmune thrombocytopenia is usually attributable to HPA-la antibodies. We report a case of parental platelet antigen incompatibility associated with a severe neonatal thrombocytopenia secondary to alloimmunization to HPA-3a. Materials and Methods: Platelet antibodies were detected by the monoclonal antibody-specific immobilization of platelet antigens, genotyping of the platelets by PCR, and HLA typing by serologic procedures and PCR. Results: Genotyping of maternal and paternal platelets confirmed the incompatibility in the HPA-3a system. It is noteworthy that the mother is of the HLA type DRB3*0101, is ABO-incompatible with her husband, and also has HLA class I antibodies. Conclusion: Severe neonatal thrombocytopenia associated with HPA-3a alloimmunization is infrequent and all the factors mentioned above could have played a role in the severity of the disease." @default.
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• W4253364891 date "1998-04-01" @default.
• W4253364891 modified "2023-09-23" @default.
• W4253364891 title "Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-3a" @default.
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• W4253364891 doi "https://doi.org/10.1046/j.1423-0410.1998.7430201.x" @default.
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