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• W4253368377 abstract "I appreciate the comments by Dr. Potters regarding our recent article in Radiation Oncology Investigations [1]. Many of Dr. Potters' comments emphasize concerns that we stated in our article: 1) “Our I-125 patients have a longer follow-up (mean = 36 months) compared with our Pd-103 patients (mean = 18 months),” and 2) “All of the conclusions in this study must be considered preliminary in nature and must be verified by larger experiences with longer follow-up.” Despite these considerations, if our article stimulates an honest debate about the relative merits of I-125 vs. Pd-103 implants, then our article will have served an important and useful purpose. Dr. Potters quotes his own article on urinary morbidity following implant and states that there was no difference in urinary complications with I-125 vs. Pd-103 [2]. However, the methodology used in Dr. Potters' study was very different from ours. The study by Dr. Potters emphasized short-term urinary complications following prostate implant with only a minor emphasis on long-term complications. Dr. Potters' data was generated from patient responses to a standard questionnaire. In contrast, our study excluded short-term urinary complications and focused only on long-term urinary complications occurring over 6–12 months following implant. In addition, our definition of long-term urinary complications was based on physician evaluation and required cystoscopy to document the underlying pathophysiology of each complication. Therefore, although the study by Dr. Potters is important, it is not directly comparable to our results. Finally, the long-term urinary complication rate in Dr. Potters' study includes a 4.7% rate of transurethral resection of the prostate (TURP) and a 1% rate of urinary incontinence [2]. In our study, no patient required a TURP, and our rate of urinary incontinence was 0% [1]. Only 3% of our patients required a minor transurethral incision for a documented urethral stricture. Such differences in outcome only highlight the fact that multiple factors may be responsible for the long-term complication rate following implant, including patient selection, proper postimplant care, and the underlying radiobiology of the tumor and normal tissues." @default.
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• W4253368377 title "Reply" @default.
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• W4253368377 doi "https://doi.org/10.1002/(sici)1097-0215(20000420)90:2<110::aid-ijc8>3.0.co;2-5" @default.
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