Matches in SemOpenAlex for { <https://semopenalex.org/work/W4253415877> ?p ?o ?g. }
- W4253415877 endingPage "682" @default.
- W4253415877 startingPage "675" @default.
- W4253415877 abstract "Adeno-associated virus (AAV) is a leading vector for virus-based gene therapy. The receptor for AAV (AAVR; also named KIAA0319L) was recently identified, and the precise characterization of AAV-AAVR recognition is in immediate demand. Taking advantage of a particle-filtering algorithm, we report here the cryo-electron microscopy structure of the AAV2-AAVR complex at 2.8 Å resolution. This structure reveals that of the five Ig-like polycystic kidney disease (PKD) domains in AAVR, PKD2 binds directly to the spike region of the AAV2 capsid adjacent to the icosahedral three-fold axis. Residues in strands B and E, and the BC loop of AAVR PKD2 interact directly with the AAV2 capsid. The interacting residues in the AAV2 capsid are mainly in AAV-featured variable regions. Mutagenesis of the amino acids at the AAV2-AAVR interface reduces binding activity and viral infectivity. Our findings provide insights into the biology of AAV entry with high-resolution details, providing opportunities for the development of new AAV vectors for gene therapy." @default.
- W4253415877 created "2022-05-12" @default.
- W4253415877 creator A5003121112 @default.
- W4253415877 creator A5012947188 @default.
- W4253415877 creator A5013370571 @default.
- W4253415877 creator A5016669094 @default.
- W4253415877 creator A5029164482 @default.
- W4253415877 creator A5038082934 @default.
- W4253415877 creator A5050227334 @default.
- W4253415877 creator A5052372262 @default.
- W4253415877 creator A5056028884 @default.
- W4253415877 creator A5064853283 @default.
- W4253415877 creator A5065241402 @default.
- W4253415877 creator A5072682170 @default.
- W4253415877 creator A5075432747 @default.
- W4253415877 creator A5090458052 @default.
- W4253415877 creator A5090797982 @default.
- W4253415877 date "2019-02-11" @default.
- W4253415877 modified "2023-10-16" @default.
- W4253415877 title "Adeno-associated virus 2 bound to its cellular receptor AAVR" @default.
- W4253415877 cites W124314106 @default.
- W4253415877 cites W1507799217 @default.
- W4253415877 cites W1965786463 @default.
- W4253415877 cites W1981950767 @default.
- W4253415877 cites W1997415237 @default.
- W4253415877 cites W2038147156 @default.
- W4253415877 cites W2046810924 @default.
- W4253415877 cites W2054723576 @default.
- W4253415877 cites W2073949924 @default.
- W4253415877 cites W2081485012 @default.
- W4253415877 cites W2085421615 @default.
- W4253415877 cites W2090441354 @default.
- W4253415877 cites W2097722745 @default.
- W4253415877 cites W2104234755 @default.
- W4253415877 cites W2120683337 @default.
- W4253415877 cites W2122304523 @default.
- W4253415877 cites W2124026197 @default.
- W4253415877 cites W2132629607 @default.
- W4253415877 cites W2133171074 @default.
- W4253415877 cites W2137702198 @default.
- W4253415877 cites W2149360962 @default.
- W4253415877 cites W2154329712 @default.
- W4253415877 cites W2266837556 @default.
- W4253415877 cites W2594616872 @default.
- W4253415877 cites W2725317673 @default.
- W4253415877 cites W2732628005 @default.
- W4253415877 cites W2765080153 @default.
- W4253415877 cites W2803869264 @default.
- W4253415877 cites W2951654089 @default.
- W4253415877 cites W2952566602 @default.
- W4253415877 cites W2994486952 @default.
- W4253415877 cites W4206826545 @default.
- W4253415877 cites W4233394827 @default.
- W4253415877 doi "https://doi.org/10.1038/s41564-018-0356-7" @default.
- W4253415877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30742069" @default.
- W4253415877 hasPublicationYear "2019" @default.
- W4253415877 type Work @default.
- W4253415877 citedByCount "66" @default.
- W4253415877 countsByYear W42534158772019 @default.
- W4253415877 countsByYear W42534158772020 @default.
- W4253415877 countsByYear W42534158772021 @default.
- W4253415877 countsByYear W42534158772022 @default.
- W4253415877 countsByYear W42534158772023 @default.
- W4253415877 crossrefType "journal-article" @default.
- W4253415877 hasAuthorship W4253415877A5003121112 @default.
- W4253415877 hasAuthorship W4253415877A5012947188 @default.
- W4253415877 hasAuthorship W4253415877A5013370571 @default.
- W4253415877 hasAuthorship W4253415877A5016669094 @default.
- W4253415877 hasAuthorship W4253415877A5029164482 @default.
- W4253415877 hasAuthorship W4253415877A5038082934 @default.
- W4253415877 hasAuthorship W4253415877A5050227334 @default.
- W4253415877 hasAuthorship W4253415877A5052372262 @default.
- W4253415877 hasAuthorship W4253415877A5056028884 @default.
- W4253415877 hasAuthorship W4253415877A5064853283 @default.
- W4253415877 hasAuthorship W4253415877A5065241402 @default.
- W4253415877 hasAuthorship W4253415877A5072682170 @default.
- W4253415877 hasAuthorship W4253415877A5075432747 @default.
- W4253415877 hasAuthorship W4253415877A5090458052 @default.
- W4253415877 hasAuthorship W4253415877A5090797982 @default.
- W4253415877 hasConcept C104317684 @default.
- W4253415877 hasConcept C111599444 @default.
- W4253415877 hasConcept C159047783 @default.
- W4253415877 hasConcept C16318435 @default.
- W4253415877 hasConcept C202878990 @default.
- W4253415877 hasConcept C2522874641 @default.
- W4253415877 hasConcept C2778107364 @default.
- W4253415877 hasConcept C40767141 @default.
- W4253415877 hasConcept C501734568 @default.
- W4253415877 hasConcept C54355233 @default.
- W4253415877 hasConcept C70721500 @default.
- W4253415877 hasConcept C86803240 @default.
- W4253415877 hasConcept C92087593 @default.
- W4253415877 hasConceptScore W4253415877C104317684 @default.
- W4253415877 hasConceptScore W4253415877C111599444 @default.
- W4253415877 hasConceptScore W4253415877C159047783 @default.
- W4253415877 hasConceptScore W4253415877C16318435 @default.
- W4253415877 hasConceptScore W4253415877C202878990 @default.
- W4253415877 hasConceptScore W4253415877C2522874641 @default.