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- W4253442029 abstract "MRI in Alzheimer's disease (AD) has primarily measured declines in grey matter thickness and volume. There is a growing interest in understanding how both grey matter microstructure and myelination are altered in AD. Previous examinations of white matter have been restricted to large fiber bundles, whereas myelin is distributed throughout the cortex. We used the ratio of intensities in a T1-weighted image (T1w) to a T2-weighted (T2w) image (T1w/T2w, or Myelin Map) to evaluate grey matter microstructure and compared this to measurements of cortical thickness (1). Participants consisted of cognitively normal individuals (n=44, mean age=74.5) and a collapsed population of participants with very mild (n=31, CDR=0.5, mean age=78) and mild (n=12, CDR=1, mean age 77) AD. Cortical thickness was estimated using Freesurfer. Estimates of cortical myelination were generated using Caret (1). Participants with dementia had widespread reductions in cortical thickness compared to controls (Figure 1). They had lower T1w/T2w ratios in primary sensory and motor cortices, which suggests a loss of cortical microstructure, likely due to demyelination. Conversely, the dementia group exhibited higher T1w/T2w ratios in the temporal lobe, medial prefrontal and cingulate cortex suggesting divergent pathological processes in those areas." @default.
- W4253442029 created "2022-05-12" @default.
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- W4253442029 date "2013-07-01" @default.
- W4253442029 modified "2023-09-27" @default.
- W4253442029 title "P1-331: Characterization of cortical microstructural changes in Alzheimer's disease" @default.
- W4253442029 doi "https://doi.org/10.1016/j.jalz.2013.05.557" @default.
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