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- W4253443224 abstract "This chapter explains concepts such as different types of DNA damage, oncogenes and tumor suppressor genes, and the hallmarks of cancer cells. There are many different reasons why the cells' DNA gets damaged. Some of this damage is natural and unavoidable, whereas some of it is down to the lifestyle, behaviors, exposures, geographical location, and even local customs. DNA mutations also come in many forms. These can divided into two groups: mutations affecting long stretches of DNA and whole chromosomes and mutations affecting just a few DNA base pairs. Most chemotherapies and radiotherapy work by causing so much DNA damage that cancer cells die. However, not every cell is killed. A major reason why many tumors fail to respond to treatment or become resistant later is intratumoral heterogeneity. The chapter also gives an overview of some other key concepts discussed in this book." @default.
- W4253443224 created "2022-05-12" @default.
- W4253443224 date "2018-05-11" @default.
- W4253443224 modified "2023-10-17" @default.
- W4253443224 title "An Introduction to Cancer Cell Biology and Genetics" @default.
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- W4253443224 doi "https://doi.org/10.1002/9781119126843.ch1" @default.
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