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• W4253449483 abstract "More than 10^4 plaque-forming units (pfu)/ml of HIV are inactivated during the alcohol fractionation step from plasma to fraction (Fr)-II+III, >10^4 pfu/ml is inactivated from Fr-II+III to Fr-II and >104 pfu/ml is inactivated during the polyethylene glycol (PEG) fractionation process from Fr-II+III to intravenous IgG (IVIG). The total inactivation rate from plasma to IVIG via Fr-II+III or Fr-II was calculated to be greater than 10^8 or 10^12, respectively. The PEG fractionation method produces an intact and unmodified IVIG. In addition, the PEG fractionation method at a low ionic strength was found to be effective for the elimination of greater than 10^5 units of other viruses, including hepatitis B, vesicular stomatitis and Sindbis viruses" @default.
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• W4253449483 date "1987-01-01" @default.
• W4253449483 modified "2023-10-16" @default.
• W4253449483 title "Elimination of Viruses (Human Immunodeficiency, Hepatitis B, Vesicular Stomatitis and Sindbis Viruses) from an Intravenous Immunoglobulin Preparation" @default.
• W4253449483 doi "https://doi.org/10.1159/000461699" @default.
• W4253449483 hasPublicationYear "1987" @default.
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