FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4253453039> ?p ?o ?g. }

• W4253453039 endingPage "841" @default.
• W4253453039 startingPage "836" @default.
• W4253453039 abstract "To compare the features of the active sites of CYP2C8, CYP2C9, and CYP2C19, homology modeling was performed based on the crystallographic coordinates of mammalian CYP2C5. It was found that CYP2C8 has a much larger pocket than the other forms due to the existence of an additional pocket. The approach to the additional pocket is comprised of Ile102, Ser114, Leu208, Val366, and Ile476, and the side chains of Ser114, Val366, and Ile476, which are smaller than the corresponding residues in the other CYPs, enable access to the pocket. The general features of the active site in the CYP2C8 model are similar to those of the previously constructed CYP3A4 model, which may account for the 2 CYPs sharing some of their substrates. The CYP2C8 model was validated by examining the bound orientation of paclitaxel and showing that it is consistent with the formation of the 6-beta hydroxylated derivative during metabolism. Docked paclitaxel was found to form a hydrogen bond with the side chain of Asn 99, which is a characteristic residue of CYP2C8 and is located in the additional pocket. Descriptors for CYP2C8 and CYP2C9 substrates were also examined with the molecular operating environment (MOE). The descriptor by which CYP2C8 and CYP2C9 substrates were classified most distinctly was found to be molar refractivity, which might be related to the longer shape and more polar nature of the active site of CYP2C8 in the CYP2C subfamily." @default.
• W4253453039 created "2022-05-12" @default.
• W4253453039 creator A5007116662 @default.
• W4253453039 creator A5044627041 @default.
• W4253453039 creator A5058387355 @default.
• W4253453039 creator A5079471927 @default.
• W4253453039 date "2004-01-01" @default.
• W4253453039 modified "2023-10-11" @default.
• W4253453039 title "Characterization of the CYP2C8 Active Site by Homology Modeling" @default.
• W4253453039 cites W1480339013 @default.
• W4253453039 cites W1520746198 @default.
• W4253453039 cites W1557742896 @default.
• W4253453039 cites W1567686906 @default.
• W4253453039 cites W1586241840 @default.
• W4253453039 cites W1667958658 @default.
• W4253453039 cites W1759188384 @default.
• W4253453039 cites W1986838867 @default.
• W4253453039 cites W2000348105 @default.
• W4253453039 cites W2019447387 @default.
• W4253453039 cites W2025557550 @default.
• W4253453039 cites W2026091066 @default.
• W4253453039 cites W2045530950 @default.
• W4253453039 cites W2046523342 @default.
• W4253453039 cites W2050456292 @default.
• W4253453039 cites W2051639214 @default.
• W4253453039 cites W2066273100 @default.
• W4253453039 cites W2070098436 @default.
• W4253453039 cites W2075717598 @default.
• W4253453039 cites W2091745408 @default.
• W4253453039 cites W2097100227 @default.
• W4253453039 cites W2106882534 @default.
• W4253453039 cites W2149319043 @default.
• W4253453039 cites W2151724311 @default.
• W4253453039 doi "https://doi.org/10.1248/cpb.52.836" @default.
• W4253453039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15256704" @default.
• W4253453039 hasPublicationYear "2004" @default.
• W4253453039 type Work @default.
• W4253453039 citedByCount "8" @default.
• W4253453039 countsByYear W42534530392017 @default.
• W4253453039 countsByYear W42534530392021 @default.
• W4253453039 crossrefType "journal-article" @default.
• W4253453039 hasAuthorship W4253453039A5007116662 @default.
• W4253453039 hasAuthorship W4253453039A5044627041 @default.
• W4253453039 hasAuthorship W4253453039A5058387355 @default.
• W4253453039 hasAuthorship W4253453039A5079471927 @default.
• W4253453039 hasBestOaLocation W42534530391 @default.
• W4253453039 hasConcept C112887158 @default.
• W4253453039 hasConcept C115368759 @default.
• W4253453039 hasConcept C159110408 @default.
• W4253453039 hasConcept C169627665 @default.
• W4253453039 hasConcept C178790620 @default.
• W4253453039 hasConcept C178910836 @default.
• W4253453039 hasConcept C181199279 @default.
• W4253453039 hasConcept C185592680 @default.
• W4253453039 hasConcept C204921945 @default.
• W4253453039 hasConcept C2776694085 @default.
• W4253453039 hasConcept C2777292972 @default.
• W4253453039 hasConcept C32909587 @default.
• W4253453039 hasConcept C3946865 @default.
• W4253453039 hasConcept C41183919 @default.
• W4253453039 hasConcept C41685203 @default.
• W4253453039 hasConcept C521977710 @default.
• W4253453039 hasConcept C526171541 @default.
• W4253453039 hasConcept C54355233 @default.
• W4253453039 hasConcept C55493867 @default.
• W4253453039 hasConcept C62231903 @default.
• W4253453039 hasConcept C71240020 @default.
• W4253453039 hasConcept C71924100 @default.
• W4253453039 hasConcept C86803240 @default.
• W4253453039 hasConceptScore W4253453039C112887158 @default.
• W4253453039 hasConceptScore W4253453039C115368759 @default.
• W4253453039 hasConceptScore W4253453039C159110408 @default.
• W4253453039 hasConceptScore W4253453039C169627665 @default.
• W4253453039 hasConceptScore W4253453039C178790620 @default.
• W4253453039 hasConceptScore W4253453039C178910836 @default.
• W4253453039 hasConceptScore W4253453039C181199279 @default.
• W4253453039 hasConceptScore W4253453039C185592680 @default.
• W4253453039 hasConceptScore W4253453039C204921945 @default.
• W4253453039 hasConceptScore W4253453039C2776694085 @default.
• W4253453039 hasConceptScore W4253453039C2777292972 @default.
• W4253453039 hasConceptScore W4253453039C32909587 @default.
• W4253453039 hasConceptScore W4253453039C3946865 @default.
• W4253453039 hasConceptScore W4253453039C41183919 @default.
• W4253453039 hasConceptScore W4253453039C41685203 @default.
• W4253453039 hasConceptScore W4253453039C521977710 @default.
• W4253453039 hasConceptScore W4253453039C526171541 @default.
• W4253453039 hasConceptScore W4253453039C54355233 @default.
• W4253453039 hasConceptScore W4253453039C55493867 @default.
• W4253453039 hasConceptScore W4253453039C62231903 @default.
• W4253453039 hasConceptScore W4253453039C71240020 @default.
• W4253453039 hasConceptScore W4253453039C71924100 @default.
• W4253453039 hasConceptScore W4253453039C86803240 @default.
• W4253453039 hasIssue "7" @default.
• W4253453039 hasLocation W42534530391 @default.
• W4253453039 hasLocation W42534530392 @default.
• W4253453039 hasOpenAccess W4253453039 @default.
• W4253453039 hasPrimaryLocation W42534530391 @default.
• W4253453039 hasRelatedWork W2028117333 @default.

• next