Matches in SemOpenAlex for { <https://semopenalex.org/work/W4253483886> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W4253483886 endingPage "786" @default.
- W4253483886 startingPage "778" @default.
- W4253483886 abstract "The anti-leukemic activity of a series of alkylphosphocholines (APCs) was studied against a panel of human leukemic cell lines (HL-60, K-562, Reh, MOLT-4, Jurkat, Ramos and Raji). Cytotoxic efficacy was measured by the MTT cell survival assay. All cell lines were found to be sensitive, except the multipotential CML-derived K-562 cell line. Flow cytometry of HL-60 cells showed a significant decrease of cells in S phase and the formation of a sub-G1 fraction. DNA fragmentation typical for programmed cell death was detected by DNA gel electrophoresis in these cells but not in any of the other leukemic lines. At concentrations below the cytotoxic range, mitogenic effects were seen in HL-60 cells after 14-hr exposure. Colony formation by K-562 cells revealed an augmented clonogenicity after exposure to APC with a short alkyl chain. In contrast, cells of lymphoid origin did not undergo DNA fragmentation or show mitogenic stimulation after exposure to APC. Normal bone marrow cells were also investigated for mitogenic and genotoxic effects. No decrease was found in the number of hematopoietic progenitors in long-term bone marrow cell cultures after exposure to APC. On the contrary, a significant increase was found after short exposure. Dodecylphosphocholine, hexadecylphosphocholine (HPC) and (octadecyl-[2-(N-methylpiperidino)-ethyl]-phosphate exhibited a mild clastogenicity at equimolar high doses on murine bone marrow cells in vivo,which is unusual for the majority of classical DNA-interacting anti-cancer drugs. In conclusion, APCs are agents with a broad spectrum of in vitro anti-leukemic effects, which lack hematological toxicity. Int. J. Cancer,77:778–786, 1998. © 1998 Wiley-Liss, Inc." @default.
- W4253483886 created "2022-05-12" @default.
- W4253483886 creator A5022970757 @default.
- W4253483886 creator A5029575769 @default.
- W4253483886 creator A5041518597 @default.
- W4253483886 creator A5064332179 @default.
- W4253483886 date "1998-08-31" @default.
- W4253483886 modified "2023-10-14" @default.
- W4253483886 title "Alkylphosphocholines: Effects on human leukemic cell lines and normal bone marrow cells" @default.
- W4253483886 doi "https://doi.org/10.1002/(sici)1097-0215(19980831)77:5<778::aid-ijc18>3.3.co;2-4" @default.
- W4253483886 hasPublicationYear "1998" @default.
- W4253483886 type Work @default.
- W4253483886 citedByCount "2" @default.
- W4253483886 crossrefType "journal-article" @default.
- W4253483886 hasAuthorship W4253483886A5022970757 @default.
- W4253483886 hasAuthorship W4253483886A5029575769 @default.
- W4253483886 hasAuthorship W4253483886A5041518597 @default.
- W4253483886 hasAuthorship W4253483886A5064332179 @default.
- W4253483886 hasBestOaLocation W42534838861 @default.
- W4253483886 hasConcept C109159458 @default.
- W4253483886 hasConcept C1491633281 @default.
- W4253483886 hasConcept C153911025 @default.
- W4253483886 hasConcept C154317977 @default.
- W4253483886 hasConcept C179464577 @default.
- W4253483886 hasConcept C185592680 @default.
- W4253483886 hasConcept C190283241 @default.
- W4253483886 hasConcept C202751555 @default.
- W4253483886 hasConcept C203014093 @default.
- W4253483886 hasConcept C2776090121 @default.
- W4253483886 hasConcept C2780007613 @default.
- W4253483886 hasConcept C28328180 @default.
- W4253483886 hasConcept C31573885 @default.
- W4253483886 hasConcept C43759708 @default.
- W4253483886 hasConcept C502942594 @default.
- W4253483886 hasConcept C54355233 @default.
- W4253483886 hasConcept C55493867 @default.
- W4253483886 hasConcept C62112901 @default.
- W4253483886 hasConcept C81885089 @default.
- W4253483886 hasConcept C86803240 @default.
- W4253483886 hasConcept C8891405 @default.
- W4253483886 hasConcept C95444343 @default.
- W4253483886 hasConceptScore W4253483886C109159458 @default.
- W4253483886 hasConceptScore W4253483886C1491633281 @default.
- W4253483886 hasConceptScore W4253483886C153911025 @default.
- W4253483886 hasConceptScore W4253483886C154317977 @default.
- W4253483886 hasConceptScore W4253483886C179464577 @default.
- W4253483886 hasConceptScore W4253483886C185592680 @default.
- W4253483886 hasConceptScore W4253483886C190283241 @default.
- W4253483886 hasConceptScore W4253483886C202751555 @default.
- W4253483886 hasConceptScore W4253483886C203014093 @default.
- W4253483886 hasConceptScore W4253483886C2776090121 @default.
- W4253483886 hasConceptScore W4253483886C2780007613 @default.
- W4253483886 hasConceptScore W4253483886C28328180 @default.
- W4253483886 hasConceptScore W4253483886C31573885 @default.
- W4253483886 hasConceptScore W4253483886C43759708 @default.
- W4253483886 hasConceptScore W4253483886C502942594 @default.
- W4253483886 hasConceptScore W4253483886C54355233 @default.
- W4253483886 hasConceptScore W4253483886C55493867 @default.
- W4253483886 hasConceptScore W4253483886C62112901 @default.
- W4253483886 hasConceptScore W4253483886C81885089 @default.
- W4253483886 hasConceptScore W4253483886C86803240 @default.
- W4253483886 hasConceptScore W4253483886C8891405 @default.
- W4253483886 hasConceptScore W4253483886C95444343 @default.
- W4253483886 hasIssue "5" @default.
- W4253483886 hasLocation W42534838861 @default.
- W4253483886 hasOpenAccess W4253483886 @default.
- W4253483886 hasPrimaryLocation W42534838861 @default.
- W4253483886 hasRelatedWork W2015509069 @default.
- W4253483886 hasRelatedWork W2110740665 @default.
- W4253483886 hasRelatedWork W2147761319 @default.
- W4253483886 hasRelatedWork W2353415333 @default.
- W4253483886 hasRelatedWork W2355259601 @default.
- W4253483886 hasRelatedWork W2358073269 @default.
- W4253483886 hasRelatedWork W2372398475 @default.
- W4253483886 hasRelatedWork W2383052687 @default.
- W4253483886 hasRelatedWork W2413532914 @default.
- W4253483886 hasRelatedWork W1957027900 @default.
- W4253483886 hasVolume "77" @default.
- W4253483886 isParatext "false" @default.
- W4253483886 isRetracted "false" @default.
- W4253483886 workType "article" @default.