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- W4253490537 abstract "The [3H]mepyramine binding to rat liver membranes was about 2-fold higher in the presence of 2 mM CaCI2 than in the absence. However, the [3H]-mepyramine binding to rat brain membranes was not affected by the presence of 2 mM CaCI2. Scatchard analysis showed that 2 mM CaCI2 did not change the affinity (KD) of liver membranes to [3H]mepyramine, but increased the binding capacity (Bmax). CaCI2 had a half maximal effect (ED50) at 3 μM and a maximal effect at concentrations of more than 10 μM. Other divalent cations, Mg++, Mn++, Sr++ and Ba++, also increased the [3H]mepyramine binding, whereas monovalent cations, Na+, K+, Li+ and Rb+, had no effect." @default.
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- W4253490537 date "1989-01-01" @default.
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- W4253490537 title "Divalent Cations Increase the Binding Capacity of the [3H]Mepyramine Binding Site, a Possible Histamine Hi Receptor, in Rat Liver Membranes" @default.
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- W4253490537 doi "https://doi.org/10.1016/s0021-5198(19)43044-8" @default.
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