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- W4253495514 abstract "In exercising humans, large cardiovascular responses occur during apnea. Such cardiovascular responses during apnea have been proposed to maintain oxygen supply to vital organs. However during apnea the blood flow and vascular conductance responses to exercising muscles are unknown. PURPOSE We performed present study to examine the blood flow and vascular conductance responses in exercising and non-exercising regions during apnea in humans. METHODS In eleven healthy subjects (eight male) who performed two-legged dynamic knee extension exercise, we measured the changes in heart rate (HR), cardiac output (CO), mean arterial pressure (MAP), arterial oxygen saturation (SaO2), forearm and leg blood flow (FBF and LBF respectively: by the ultrasound Doppler method) during apnea. RESULTS During apnea significant decrease in SaO2 (98±0.4 vs. 84±2.5 %, before apnea vs. peak response during apnea, P < 0.05), HR (90±1.5 vs. 54±2.0 beats min−1, P < 0.05), CO (9.7±0.7 vs. 4.5±0.5 l min−1, P < 0.05), total vascular conductance (TVC; 99.8±4.1 vs. 35.2±2.2 ml min−1 mmHg−1, P < 0.05), FBF (115±8.1 vs. 17±2.3 ml min−1, P < 0.05), LBF (2229±69.1 vs. 571±62.4 ml min−1, P < 0.05), forearm vascular conductance (1.21±0.09 vs. 0.14±0.02 ml min−1 mmHg−1, P < 0.05) and leg vascular conductance (LVC: 23.10±0.75 vs. 4.30±0.47 ml min−1 mmHg−1, P < 0.05) and significant increase in MAP (97±2.4 vs. 148±3.9 mmHg, P < 0.05) were observed. At late stage of apnea, LBF decreased to 26±3.8 % of before apnea value. The decrease in vascular conductance in both legs (calculated as LVC × 2) was estimated to be 61±5.2 % of the decrease in TVC. CONCLUSIONS During apnea very marked vasoconstriction in exercising limb occurs and this vascular response in exercising region would play a huge role in defending blood flow to vital organs against the apnea induced hypoxemia. Supported by grants from COE projects, and from the Ministry of Education, Science, and Culture, Japan." @default.
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- W4253495514 date "2005-05-01" @default.
- W4253495514 modified "2023-09-25" @default.
- W4253495514 title "The Changes In Vascular Conductance In Exercising Limb During Apnea In Humans" @default.
- W4253495514 doi "https://doi.org/10.1249/00005768-200505001-01181" @default.
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