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- W4253552892 abstract "Neuropeptides constitute a large and diverse class of signaling molecules that are produced by many types of neurons, neurosecretory cells, endocrines and other cells. Many neuropeptides display pleiotropic actions either as neuromodulators, co-transmitters or circulating hormones, while some play these roles concurrently. Here, we highlight pleiotropic functions of neuropeptides and different levels of neuropeptide signaling in the brain, from context-dependent orchestrating signaling by higher order neurons, to local executive modulation in specific circuits. Additionally, orchestrating neurons receive peptidergic signals from neurons conveying organismal internal state cues and relay these to executive circuits. We exemplify these levels of signaling with four neuropeptides, SIFamide, short neuropeptide F, allatostatin-A and leucokinin, each with a specific expression pattern and level of complexity in signaling." @default.
- W4253552892 created "2022-05-12" @default.
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- W4253552892 date "2019-02-11" @default.
- W4253552892 modified "2023-10-18" @default.
- W4253552892 title "Neuropeptides in modulation of Drosophila behavior: how to get a grip on their pleiotropic actions" @default.
- W4253552892 doi "https://doi.org/10.7287/peerj.preprints.27531v1" @default.
- W4253552892 hasPublicationYear "2019" @default.
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