Matches in SemOpenAlex for { <https://semopenalex.org/work/W4253577699> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W4253577699 abstract "Background and Purpose: Dexamethasone is widely used in preterm labor and related diseases. However, prenatal dexamethasone exposure (PDE) can cause multi-organ developmental toxicities in offspring. Our previous study found the occurrence of fetal-originated diseases were associated with adrenal developmental programming alteration in offspring. Here, we investigated the effects of PDE on the adrenal function in offspring and its intrauterine programming mechanism. Experimental Approach: A rat model of PDE was established to observe the alteration of adrenal steroidogenesis in offspring. Further, we confirmed the gender difference of adrenal steroidogenesis and its molecular mechanism combined with in vivo and in vitro experiment. Key Results: PDE caused a decrease in adrenal steroidogenic function in fetal rats, but decreased in males and increased in females after birth. Meanwhile, the adrenal H3K14ac level and expression of 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2) in PDE offspring were decreased in males and increased in females, suggesting 11β-HSD2 might mediate gender difference of adrenal function. We further confirmed dexamethasone inhibited the H3K14ac level and expression of 11β-HSD2 through GR/SP1/p300 pathway. After bilateral testectomy or ovariectomy in adult PDE offspring rats, adrenal 11β-HSD2 expression and steroidogenic function were both reduced. Using rat primary fetal adrenal cells, the differential expression in AR and ERβ were proved to involve in regulating the gender difference of 11β-HSD2 expression. Conclusion and Implications: This study demonstrated the gender difference in adrenal steroidogenic function of PDE offspring after birth, and elucidates a sex hormone receptor-dependent epigenetically regulating mechanism for adrenal 11β-HSD2 programming alteration." @default.
- W4253577699 created "2022-05-12" @default.
- W4253577699 creator A5000758800 @default.
- W4253577699 creator A5005494911 @default.
- W4253577699 creator A5015741637 @default.
- W4253577699 creator A5024188231 @default.
- W4253577699 creator A5041817800 @default.
- W4253577699 creator A5069680429 @default.
- W4253577699 creator A5072904721 @default.
- W4253577699 creator A5090366405 @default.
- W4253577699 date "2021-03-31" @default.
- W4253577699 modified "2023-09-26" @default.
- W4253577699 title "Gender difference in adrenal developmental toxicity induced by dexamethasone and its intrauterine programming mechanism" @default.
- W4253577699 doi "https://doi.org/10.22541/au.161722689.97666138/v1" @default.
- W4253577699 hasPublicationYear "2021" @default.
- W4253577699 type Work @default.
- W4253577699 citedByCount "0" @default.
- W4253577699 crossrefType "posted-content" @default.
- W4253577699 hasAuthorship W4253577699A5000758800 @default.
- W4253577699 hasAuthorship W4253577699A5005494911 @default.
- W4253577699 hasAuthorship W4253577699A5015741637 @default.
- W4253577699 hasAuthorship W4253577699A5024188231 @default.
- W4253577699 hasAuthorship W4253577699A5041817800 @default.
- W4253577699 hasAuthorship W4253577699A5069680429 @default.
- W4253577699 hasAuthorship W4253577699A5072904721 @default.
- W4253577699 hasAuthorship W4253577699A5090366405 @default.
- W4253577699 hasBestOaLocation W42535776991 @default.
- W4253577699 hasConcept C112672928 @default.
- W4253577699 hasConcept C126322002 @default.
- W4253577699 hasConcept C134018914 @default.
- W4253577699 hasConcept C172680121 @default.
- W4253577699 hasConcept C2779234561 @default.
- W4253577699 hasConcept C2780401358 @default.
- W4253577699 hasConcept C3017452174 @default.
- W4253577699 hasConcept C54355233 @default.
- W4253577699 hasConcept C71315377 @default.
- W4253577699 hasConcept C71924100 @default.
- W4253577699 hasConcept C86803240 @default.
- W4253577699 hasConceptScore W4253577699C112672928 @default.
- W4253577699 hasConceptScore W4253577699C126322002 @default.
- W4253577699 hasConceptScore W4253577699C134018914 @default.
- W4253577699 hasConceptScore W4253577699C172680121 @default.
- W4253577699 hasConceptScore W4253577699C2779234561 @default.
- W4253577699 hasConceptScore W4253577699C2780401358 @default.
- W4253577699 hasConceptScore W4253577699C3017452174 @default.
- W4253577699 hasConceptScore W4253577699C54355233 @default.
- W4253577699 hasConceptScore W4253577699C71315377 @default.
- W4253577699 hasConceptScore W4253577699C71924100 @default.
- W4253577699 hasConceptScore W4253577699C86803240 @default.
- W4253577699 hasLocation W42535776991 @default.
- W4253577699 hasOpenAccess W4253577699 @default.
- W4253577699 hasPrimaryLocation W42535776991 @default.
- W4253577699 hasRelatedWork W117621442 @default.
- W4253577699 hasRelatedWork W1591616590 @default.
- W4253577699 hasRelatedWork W1963881727 @default.
- W4253577699 hasRelatedWork W1977972276 @default.
- W4253577699 hasRelatedWork W2009428258 @default.
- W4253577699 hasRelatedWork W2064652474 @default.
- W4253577699 hasRelatedWork W2067693794 @default.
- W4253577699 hasRelatedWork W2110681150 @default.
- W4253577699 hasRelatedWork W2153052119 @default.
- W4253577699 hasRelatedWork W3160140598 @default.
- W4253577699 isParatext "false" @default.
- W4253577699 isRetracted "false" @default.
- W4253577699 workType "article" @default.