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- W4253599898 abstract "The first evidence demonstrating that leukoregulin is a unique lymphokine was found during the study of the biologic effects of Syrian hamster lymphotoxin (1). Hamster lymphotoxin preparations, in addition to the ability to lyse the murine L-929 cell line, also inhibited the growth of hamster tumor cells and could inhibit the chemical or radiation-induced carcinogenic transformation of normal hamster fetal fibroblasts (2–5). This activity was initially attributed to lymphotoxin, but after extensive biochemical characterization, an anti-hamster tumor cell and anticarcinogenic activity could be physically separated from lymphotoxin as well as interferon, interleukins, and macrophage activity factor (1). Subsequent studies of human lymphokine preparations also demonstrated that a unique molecular species was responsible for the cytotoxicity of numerous human tumor cell lines (6). This lymphokine was termed leukoregulin. This chapter discusses the evidence supporting the unique identity of human leukoregulin and its effects on human tumor cells." @default.
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- W4253599898 date "1988-01-01" @default.
- W4253599898 modified "2023-09-24" @default.
- W4253599898 title "Leukoregulin" @default.
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- W4253599898 doi "https://doi.org/10.1007/978-1-4612-4586-5_10" @default.
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