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- W4253603586 abstract "The light (L) and heavy (H) chain and the idiotypic (Id) composition of the antibody (Ab) plaque-forming cells (PFC) and serum Ab specific for α-1, 3 dextran have been characterized in murine strains exhibiting the CH-lg-l bto e allotypes and in their F1 hybrids with lg-lal, BALB/c prototypes, The Ab response of the Ig-lb to e mice to the α-1, 3 dextran was low in the kappa (K) L chain class with only a minor, sporadic Ab in the lambda (λ) L chain class discernible after prolonged immunization. Two of a total of sixty-eight C57BI/6 Ig-lb mice, in a total of 318 Ig-lb to e mice tested, exhibited, in late responses, a significantly elevated Ab in the λ L class at both serum and PFC levels, equalling at the PFC level the total non-specific λ PFC values. An Id analysis showed this λ Ab and the K Ab to lack the Id relatedness to the three BALB/c α-1, 3 dextran-binding myeloma proteins (MP) Ab prototypes, J-558, 104 E, and UPC-102, exhibited by the λ Id’ Ab of the lg-lal BALB/c prototypes and their F1 hybrids with the Ig-lb to e prototypes. Furthermore, affinity differences could be detected by α-1, 3 nigerodextrans, PFC inhibition analysis, between the late C57BI/6 anti-α-1, 3 dextran λ Id−Ab PFC and the λ Id+ Ab PFC of the BALB/c and their F1 progeny." @default.
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- W4253603586 date "1979-03-01" @default.
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- W4253603586 title "V and C Gene Contribution in Creating Anti-alpha-1, 3 Dextran Antibodies in Mice." @default.
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- W4253603586 doi "https://doi.org/10.1111/j.1365-3083.1979.tb02724.x" @default.
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