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- W4253604254 abstract "Abstract Background Accumulating evidence suggests that Gamma-glutamyltransferase (GGT) may be involved in cancer occurrence and progression. However, a prognostic role of serum GGT in pancreatic cancer (PC) survival lacks adequate evaluation. In this study, we aimed to analyze the association between serum GGT measured at diagnosis and overall survival (OS) in patients with metastatic PC. Methods We identified 320 patients with histopathologically confirmed metastatic pancreatic ductal adenocarcinoma (PDAC) diagnosed during 2015 and 2016 at a specialized cancer hospital in southwest China. Univariate and multivariate Cox proportional hazards models were used to determine associations between serum GGT and OS in metastatic PDAC. Results Under control for possible confounding factors, serum GGT was significantly associated with OS: serum GGT >48 U/L yielded a hazard ratio of 1.53 (95%CI: 1.19-1.97) for mortality risk. Significant dose-response between serum GGT and OS was also observed. Subgroup analysis showed some evidence for an interaction between GGT and blood glucose level. Conclusion Serum GGT could be a promising indicator of survival in metastatic PDAC patients. Underlying mechanisms for this association should be investigated." @default.
- W4253604254 created "2022-05-12" @default.
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- W4253604254 date "2019-07-02" @default.
- W4253604254 modified "2023-09-29" @default.
- W4253604254 title "Serum gamma-glutamyltransferase and the overall survival of metastatic pancreatic cancer" @default.
- W4253604254 doi "https://doi.org/10.21203/rs.2.10892/v1" @default.
- W4253604254 hasPublicationYear "2019" @default.
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