FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4253607372> ?p ?o ?g. }

• W4253607372 endingPage "e7" @default.
• W4253607372 startingPage "e6" @default.
• W4253607372 abstract "We appreciate this opportunity to respond to concerns regarding our clinical trial.1Prajna N.V. Radhakrishnan N. Lalitha P. et al.Cross-linking-assisted infection reduction: a randomized clinical trial evaluating the effect of adjuvant cross-linking on outcomes in fungal keratitis.Ophthalmology. 2020; 127: 159-166Abstract Full Text Full Text PDF PubMed Scopus (30) Google Scholar This trial studied the Dresden protocol, approved by the US Food and Drug Administration, with 1 small modification; we debrided the cornea over the area of infiltrate only. Given that baseline median infiltrate size is outlined in Table 1 (in the original article), the approximate fluence delivered to the average ulcer can be estimated. We certainly agree that this protocol may be optimized in the future and that it is a worthy area of future study. We note that the important work Hafezi et al have done in this area has focused around bacterial and not fungal keratitis. We would point out that photochemically activated riboflavin has much more antibacterial than antifungal effect in vitro; therefore, small adjustments to the protocol are likely to make more of a difference in bacterial keratitis.2Martins S.A. Combs J.C. Noguera G. et al.Antimicrobial efficacy of riboflavin/UVA combination (365 nm) in vitro for bacterial and fungal isolates: a potential new treatment for infectious keratitis.Invest Ophthalmol Vis Sci. 2008; 49: 3402-3408Crossref PubMed Scopus (191) Google Scholar,3Sauer A. Letscher-Bru V. Speeg-Schatz C. et al.In vitro efficacy of antifungal treatment using riboflavin/UV-A (365 nm) combination and amphotericin B.Invest Ophthalmol Vis Sci. 2010; 51: 3950-3953Crossref PubMed Scopus (70) Google Scholar Finally, our study suggested visual acuity outcomes and scar sizes were worse among study participants randomized to corneal crosslinking, which may limit the application of this therapy regardless of its antimicrobial effects. It is difficult to know whether an intervention is effective until it is tested in a randomized clinical trial; therefore, we look forward to seeing the results of the Swiss PACK-CXL trial as well as our own National Institutes of Health-funded bacterial keratitis trial, Steroids and Cross-linking for Ulcer Treatment. Re: Prajna et al.: Cross-Linking—Assisted Infection Reduction: a randomized clinical trial evaluating the effect of adjuvant cross-linking on outcomes in fungal keratitis (Ophthalmology. 2020;127:159–166)OphthalmologyVol. 128Issue 1PreviewPrajna et al1 published a randomized controlled clinical trial of corneal crosslinking (CXL) for the treatment of filamental fungal keratitis. They concluded, “there appears to be no benefit of adjuvant CXL in the primary treatment of moderate filamentous fungal ulcers, and it may result in decreased visual acuity.” Full-Text PDF" @default.
• W4253607372 created "2022-05-12" @default.
• W4253607372 creator A5004140941 @default.
• W4253607372 creator A5035227516 @default.
• W4253607372 creator A5069369290 @default.
• W4253607372 creator A5070550041 @default.
• W4253607372 creator A5075952432 @default.
• W4253607372 creator A5080095497 @default.
• W4253607372 creator A5087014948 @default.
• W4253607372 date "2021-01-01" @default.
• W4253607372 modified "2023-09-30" @default.
• W4253607372 title "Reply" @default.
• W4253607372 cites W1967148251 @default.
• W4253607372 cites W2074618935 @default.
• W4253607372 cites W2985963434 @default.
• W4253607372 doi "https://doi.org/10.1016/j.ophtha.2020.07.014" @default.
• W4253607372 hasPublicationYear "2021" @default.
• W4253607372 type Work @default.
• W4253607372 citedByCount "0" @default.
• W4253607372 crossrefType "journal-article" @default.
• W4253607372 hasAuthorship W4253607372A5004140941 @default.
• W4253607372 hasAuthorship W4253607372A5035227516 @default.
• W4253607372 hasAuthorship W4253607372A5069369290 @default.
• W4253607372 hasAuthorship W4253607372A5070550041 @default.
• W4253607372 hasAuthorship W4253607372A5075952432 @default.
• W4253607372 hasAuthorship W4253607372A5080095497 @default.
• W4253607372 hasAuthorship W4253607372A5087014948 @default.
• W4253607372 hasBestOaLocation W42536073721 @default.
• W4253607372 hasConcept C118487528 @default.
• W4253607372 hasConcept C126322002 @default.
• W4253607372 hasConcept C16005928 @default.
• W4253607372 hasConcept C2776882836 @default.
• W4253607372 hasConcept C2778560704 @default.
• W4253607372 hasConcept C2779548794 @default.
• W4253607372 hasConcept C535046627 @default.
• W4253607372 hasConcept C71924100 @default.
• W4253607372 hasConceptScore W4253607372C118487528 @default.
• W4253607372 hasConceptScore W4253607372C126322002 @default.
• W4253607372 hasConceptScore W4253607372C16005928 @default.
• W4253607372 hasConceptScore W4253607372C2776882836 @default.
• W4253607372 hasConceptScore W4253607372C2778560704 @default.
• W4253607372 hasConceptScore W4253607372C2779548794 @default.
• W4253607372 hasConceptScore W4253607372C535046627 @default.
• W4253607372 hasConceptScore W4253607372C71924100 @default.
• W4253607372 hasIssue "1" @default.
• W4253607372 hasLocation W42536073721 @default.
• W4253607372 hasOpenAccess W4253607372 @default.
• W4253607372 hasPrimaryLocation W42536073721 @default.
• W4253607372 hasRelatedWork W1493311709 @default.
• W4253607372 hasRelatedWork W1998197920 @default.
• W4253607372 hasRelatedWork W2473894363 @default.
• W4253607372 hasRelatedWork W2800695261 @default.
• W4253607372 hasRelatedWork W3028375176 @default.
• W4253607372 hasRelatedWork W3028635786 @default.
• W4253607372 hasRelatedWork W3168870851 @default.
• W4253607372 hasRelatedWork W3217766689 @default.
• W4253607372 hasRelatedWork W38312103 @default.
• W4253607372 hasRelatedWork W4297184974 @default.
• W4253607372 hasVolume "128" @default.
• W4253607372 isParatext "false" @default.
• W4253607372 isRetracted "false" @default.
• W4253607372 workType "article" @default.