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- W4253631460 abstract "Publisher SummaryThis chapter presents an introduction to the book Affinity Chromatography, Volume 12. The fundamental principle of affinity chromatography consists—in the utilization of the exceptional property of biologically active substances to form stable, specific and reversible complexes. If one of the components of the complex is immobilized, a specific sorbent is formed for the second component of the complex, with the assumption, of course, that all of the conditions necessary for the formation of this complex are maintained. The binding sites of the immobilized substances must retain good steric accessibility after their binding to the solid carrier, and they must not be deformed. The first examples of specific sorbents prepared by covalent bonding to a solid support were immobilized antigens. The methods developed for the attachment of antigens and antibodies to solid supports were used immediately for the preparation of immobilized enzymes; at the same time, the earlier method of binding enzymes to cellulose by means of an azide bond began to be used for the preparation of immunosorbents. The simplified isolation of enzymes by affinity chromatography promises the preparation of required amounts of enzymes at lower cost. The immobilization of enzymes on suitable carriers considerably increases the versatility of their use and thus also their economic availability." @default.
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- W4253631460 date "1978-01-01" @default.
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- W4253631460 title "Chapter 1 Introduction" @default.
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- W4253631460 doi "https://doi.org/10.1016/s0301-4770(08)60574-6" @default.
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