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• W4253643232 abstract "Acidity and hypoxia are both pivotal features in diseases such as cardiovascular disease, inflammation, ischaemia, stroke and chronic lung disease. The intracellular microenvironment shows different pH values such as pH 7.2 in cytosol and pH 4.0–6.0 in lysosomes and endosomes; however, variations of pH exceeding 0.1–0.2 units will lead to various diseases and may even be life threatening. Hypoxia, particularly in tumours, triggers series of cases and therapy blockade. Therefore, monitoring of pH fluctuations and hypoxia will afford important information about disease analysis and diagnosis, which are of great significance in acquiring a deep understanding of various disordered pathophysiological processes and therapy results. Molecular and nanomaterials have proved to be excellent tools for in situ imaging of non-normal events such as abnormal pH and hypoxia in lesion areas. This chapter focuses on recent advances in the fluorescence imaging of tumour pH and hypoxia and their biological application in tumour therapeutic monitoring." @default.
• W4253643232 created "2022-05-12" @default.
• W4253643232 date "2020-01-28" @default.
• W4253643232 modified "2023-09-24" @default.
• W4253643232 title "Imaging of the Tumour Microenvironment" @default.
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• W4253643232 doi "https://doi.org/10.1039/9781839160455-00211" @default.
• W4253643232 hasPublicationYear "2020" @default.
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