FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4253660343> ?p ?o ?g. }

• W4253660343 endingPage "22" @default.
• W4253660343 startingPage "16" @default.
• W4253660343 abstract "Changes in the level of GAP-43 and its mRNA in nigrostriatal dopaminergic neurons in an animal model of the presymptomatic period of Parkinson's disease were measured to find the characteristic features of GAP-43 in nigrostriatal dopaminergic neurons. Since the dopaminergic neurons possess a relatively large amount of GAP-43 protein and mRNA, the dopaminergic neurons must be endowed with specific functions related to those of GAP-43. In this study, dopaminergic axon terminals were partially destroyed by intrastriatal 6-hydroxydopamine (6-OHDA). Rats were decapitated 3, 14, and 56 days following treatment. Levels of GAP-43 and tyrosine hydroxylase (TH) in the striatum were detected by immunoblotting and quantified. The number of GAP-43 mRNA-positive neurons and that of TH mRNA-positive neurons in the substantia nigra pars compacta (SNc) were detected by in situ hybridization using alkaline phosphatase (ALP)-labeled probes. Levels of GAP-43 in the striatum showed no significant alteration during the period of the experiment, although levels of TH were gradually restored. The number of GAP-43 mRNA-positive neurons as well as that of TH mRNA-positive neurons in the SNc decreased. These results suggests that dopaminergic neurons restore their axon terminals with little change in GAP-43, and that transcription and/or stability of GAP-43 mRNA in the dopaminergic neurons are susceptible to the toxin, although the dopaminergic neurons can maintain the translational product in the terminals. This feature may be related with a degeneration of dopaminergic neurons in Parkinson's disease." @default.
• W4253660343 created "2022-05-12" @default.
• W4253660343 creator A5022356063 @default.
• W4253660343 creator A5027866038 @default.
• W4253660343 creator A5067195079 @default.
• W4253660343 date "2000-01-01" @default.
• W4253660343 modified "2023-09-26" @default.
• W4253660343 title "Regulation of GAP-43 protein and mRNA in nigrostriatal dopaminergic neurons after the partial destruction of dopaminergic terminals with intrastriatal 6-hydroxydopamine" @default.
• W4253660343 cites W1495696399 @default.
• W4253660343 cites W1503846663 @default.
• W4253660343 cites W1524258826 @default.
• W4253660343 cites W1548296683 @default.
• W4253660343 cites W1609357790 @default.
• W4253660343 cites W1842081459 @default.
• W4253660343 cites W1900066504 @default.
• W4253660343 cites W1924760826 @default.
• W4253660343 cites W1946088410 @default.
• W4253660343 cites W1967018739 @default.
• W4253660343 cites W1972431962 @default.
• W4253660343 cites W1973980506 @default.
• W4253660343 cites W1975972710 @default.
• W4253660343 cites W1979179603 @default.
• W4253660343 cites W1982646058 @default.
• W4253660343 cites W1984810645 @default.
• W4253660343 cites W1991839230 @default.
• W4253660343 cites W1992785510 @default.
• W4253660343 cites W1998532128 @default.
• W4253660343 cites W1998761186 @default.
• W4253660343 cites W2001775202 @default.
• W4253660343 cites W2002813350 @default.
• W4253660343 cites W2009702200 @default.
• W4253660343 cites W2010601153 @default.
• W4253660343 cites W2010775349 @default.
• W4253660343 cites W2011915299 @default.
• W4253660343 cites W2016336099 @default.
• W4253660343 cites W2016904778 @default.
• W4253660343 cites W2018782975 @default.
• W4253660343 cites W2019019227 @default.
• W4253660343 cites W2020846299 @default.
• W4253660343 cites W2023458956 @default.
• W4253660343 cites W2029246446 @default.
• W4253660343 cites W2035388674 @default.
• W4253660343 cites W2042261016 @default.
• W4253660343 cites W2050055911 @default.
• W4253660343 cites W2050636568 @default.
• W4253660343 cites W2053632669 @default.
• W4253660343 cites W2056587633 @default.
• W4253660343 cites W2057217877 @default.
• W4253660343 cites W2062898068 @default.
• W4253660343 cites W2065000444 @default.
• W4253660343 cites W2067435357 @default.
• W4253660343 cites W2071380535 @default.
• W4253660343 cites W2074279043 @default.
• W4253660343 cites W2082106963 @default.
• W4253660343 cites W2085415388 @default.
• W4253660343 cites W2087547292 @default.
• W4253660343 cites W2087592242 @default.
• W4253660343 cites W2103380620 @default.
• W4253660343 cites W2106279306 @default.
• W4253660343 cites W2118851646 @default.
• W4253660343 cites W2153427564 @default.
• W4253660343 doi "https://doi.org/10.1002/1098-2396(20010101)39:1<16::aid-syn3>3.0.co;2-" @default.
• W4253660343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11071705" @default.
• W4253660343 hasPublicationYear "2000" @default.
• W4253660343 type Work @default.
• W4253660343 citedByCount "6" @default.
• W4253660343 countsByYear W42536603432016 @default.
• W4253660343 countsByYear W42536603432017 @default.
• W4253660343 countsByYear W42536603432019 @default.
• W4253660343 crossrefType "journal-article" @default.
• W4253660343 hasAuthorship W4253660343A5022356063 @default.
• W4253660343 hasAuthorship W4253660343A5027866038 @default.
• W4253660343 hasAuthorship W4253660343A5067195079 @default.
• W4253660343 hasConcept C126322002 @default.
• W4253660343 hasConcept C134018914 @default.
• W4253660343 hasConcept C137183658 @default.
• W4253660343 hasConcept C159167319 @default.
• W4253660343 hasConcept C169760540 @default.
• W4253660343 hasConcept C2776286997 @default.
• W4253660343 hasConcept C2776355744 @default.
• W4253660343 hasConcept C2776773494 @default.
• W4253660343 hasConcept C2777288102 @default.
• W4253660343 hasConcept C2779134260 @default.
• W4253660343 hasConcept C2779530196 @default.
• W4253660343 hasConcept C2779734285 @default.
• W4253660343 hasConcept C2780062018 @default.
• W4253660343 hasConcept C2780938664 @default.
• W4253660343 hasConcept C2911016594 @default.
• W4253660343 hasConcept C513476851 @default.
• W4253660343 hasConcept C71924100 @default.
• W4253660343 hasConcept C86803240 @default.
• W4253660343 hasConceptScore W4253660343C126322002 @default.
• W4253660343 hasConceptScore W4253660343C134018914 @default.
• W4253660343 hasConceptScore W4253660343C137183658 @default.
• W4253660343 hasConceptScore W4253660343C159167319 @default.
• W4253660343 hasConceptScore W4253660343C169760540 @default.
• W4253660343 hasConceptScore W4253660343C2776286997 @default.
• W4253660343 hasConceptScore W4253660343C2776355744 @default.

• next