Matches in SemOpenAlex for { <https://semopenalex.org/work/W4253674218> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4253674218 abstract "Abstract Background: The high-temperature requirement factor A1 (HTRA1) gene at the 10q26 locus has been associated with age-related macular degenerative (AMD) risk, with the significantly associated polymorphism being (rs11200638, -625G/A), however, above association is not consistent. We investigated an updated meta-analysis to evaluate the association between rs11200638 polymorphism and AMD risk thoroughly addressing this issue. Methods: An identification was covered with the Pubmed and Chinese Wanfang databases through 27th Jan, 2020. Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of associations. After a thorough and meticulous search, 35 different articles (33 case-control studies with HWE, 22 case-control studies about wet/dry AMD) were retrieved. Results: Individuals carrying A-allele or AA genotype may have an increased risk to be AMD disease. For example, there has a significantly increased relationship between rs11200638 polymorphism and AMD both for Asians (OR: 2.51, 95%CI: 2.22-2.83 for A-allele vs. G-allele) and Caucasians (OR: 2.63, 95%CI: 2.29-3.02 for A-allele vs. G-allele). Moreover, a similar trend in the source of control subgroup was detected. To classify the type of AMD, increased association was also observed in both wet (OR: 3.40, 95%CI: 2.90-3.99 for dominant model) and dry (OR: 2.08, 95%CI: 1.24-3.48 for dominant model) AMD. Finally, based on the different genotyping methods, increased relationships were identified by sequencing, TaqMan, PCR-RFLP and RT-PCR. Conclusions: Our present meta-analysis suggests that the HTRA1 rs11200638 polymorphism are potentially associated with the risk of AMD development, especially about individuals carrying A-allele or AA genotype, who may be as identified targets to detect and intervene in advance. Further studies using larger sample sizes and including information about gene-environment interactions should be conducted to elucidate." @default.
- W4253674218 created "2022-05-12" @default.
- W4253674218 creator A5035841088 @default.
- W4253674218 creator A5060002817 @default.
- W4253674218 creator A5067046651 @default.
- W4253674218 creator A5078400783 @default.
- W4253674218 date "2020-05-14" @default.
- W4253674218 modified "2023-09-27" @default.
- W4253674218 title "High-temperature requirement factor A1 rs11200638 polymorphism and age-related macular degenerative from a comprehensive analysis about 15316 subjects" @default.
- W4253674218 doi "https://doi.org/10.21203/rs.2.23339/v4" @default.
- W4253674218 hasPublicationYear "2020" @default.
- W4253674218 type Work @default.
- W4253674218 citedByCount "0" @default.
- W4253674218 crossrefType "posted-content" @default.
- W4253674218 hasAuthorship W4253674218A5035841088 @default.
- W4253674218 hasAuthorship W4253674218A5060002817 @default.
- W4253674218 hasAuthorship W4253674218A5067046651 @default.
- W4253674218 hasAuthorship W4253674218A5078400783 @default.
- W4253674218 hasBestOaLocation W42536742181 @default.
- W4253674218 hasConcept C104317684 @default.
- W4253674218 hasConcept C126322002 @default.
- W4253674218 hasConcept C135763542 @default.
- W4253674218 hasConcept C143998085 @default.
- W4253674218 hasConcept C146304588 @default.
- W4253674218 hasConcept C156957248 @default.
- W4253674218 hasConcept C180754005 @default.
- W4253674218 hasConcept C31467283 @default.
- W4253674218 hasConcept C44249647 @default.
- W4253674218 hasConcept C54355233 @default.
- W4253674218 hasConcept C71924100 @default.
- W4253674218 hasConcept C84597430 @default.
- W4253674218 hasConcept C86803240 @default.
- W4253674218 hasConceptScore W4253674218C104317684 @default.
- W4253674218 hasConceptScore W4253674218C126322002 @default.
- W4253674218 hasConceptScore W4253674218C135763542 @default.
- W4253674218 hasConceptScore W4253674218C143998085 @default.
- W4253674218 hasConceptScore W4253674218C146304588 @default.
- W4253674218 hasConceptScore W4253674218C156957248 @default.
- W4253674218 hasConceptScore W4253674218C180754005 @default.
- W4253674218 hasConceptScore W4253674218C31467283 @default.
- W4253674218 hasConceptScore W4253674218C44249647 @default.
- W4253674218 hasConceptScore W4253674218C54355233 @default.
- W4253674218 hasConceptScore W4253674218C71924100 @default.
- W4253674218 hasConceptScore W4253674218C84597430 @default.
- W4253674218 hasConceptScore W4253674218C86803240 @default.
- W4253674218 hasLocation W42536742181 @default.
- W4253674218 hasLocation W42536742182 @default.
- W4253674218 hasLocation W42536742183 @default.
- W4253674218 hasOpenAccess W4253674218 @default.
- W4253674218 hasPrimaryLocation W42536742181 @default.
- W4253674218 hasRelatedWork W121700474 @default.
- W4253674218 hasRelatedWork W132287889 @default.
- W4253674218 hasRelatedWork W1901616783 @default.
- W4253674218 hasRelatedWork W1965247597 @default.
- W4253674218 hasRelatedWork W1987667788 @default.
- W4253674218 hasRelatedWork W2031382594 @default.
- W4253674218 hasRelatedWork W2393464409 @default.
- W4253674218 hasRelatedWork W3030770765 @default.
- W4253674218 hasRelatedWork W4313828760 @default.
- W4253674218 hasRelatedWork W4321164336 @default.
- W4253674218 isParatext "false" @default.
- W4253674218 isRetracted "false" @default.
- W4253674218 workType "article" @default.