Matches in SemOpenAlex for { <https://semopenalex.org/work/W4253701173> ?p ?o ?g. }
- W4253701173 endingPage "14112" @default.
- W4253701173 startingPage "14108" @default.
- W4253701173 abstract "Abstract C−H activation methods for peptide macrocyclization have the potential to provide peptidomimetics and cyclic peptides with expanded structural diversity. Now, a highly versatile peptide macrocyclization strategy via late‐stage palladium‐catalyzed δ‐C(sp 2 )−H olefination of phenylalanine residues has been developed. This method utilizes peptide backbone amides as internal directing groups and allows facile macrocyclization of peptides in the N‐to‐C direction. Combined with the previously developed β‐C(sp 3 )−H arylation method for peptide macrocyclization in the C‐to‐N direction, a pair of palladium‐catalyzed reactions were obtained that are directionally orthogonal, and the first example of one‐pot synthesis of bicyclic peptides via Pd‐catalyzed β‐C(sp 3 )−H and δ‐C(sp 2 )−H activation is demonstrated." @default.
- W4253701173 created "2022-05-12" @default.
- W4253701173 creator A5029862927 @default.
- W4253701173 creator A5050146687 @default.
- W4253701173 creator A5054485777 @default.
- W4253701173 creator A5071459078 @default.
- W4253701173 date "2018-09-24" @default.
- W4253701173 modified "2023-10-16" @default.
- W4253701173 title "Backbone‐Enabled Directional Peptide Macrocyclization through Late‐Stage Palladium‐Catalyzed δ‐C(sp<sup>2</sup>)−H Olefination" @default.
- W4253701173 cites W1557267582 @default.
- W4253701173 cites W1860382351 @default.
- W4253701173 cites W1965819962 @default.
- W4253701173 cites W1968902595 @default.
- W4253701173 cites W197482517 @default.
- W4253701173 cites W1976938557 @default.
- W4253701173 cites W1981300064 @default.
- W4253701173 cites W1982782947 @default.
- W4253701173 cites W1987063095 @default.
- W4253701173 cites W1999821500 @default.
- W4253701173 cites W2008845432 @default.
- W4253701173 cites W2011539303 @default.
- W4253701173 cites W2014171031 @default.
- W4253701173 cites W2019004128 @default.
- W4253701173 cites W2023018411 @default.
- W4253701173 cites W2026059754 @default.
- W4253701173 cites W2027471446 @default.
- W4253701173 cites W2030226664 @default.
- W4253701173 cites W2040576705 @default.
- W4253701173 cites W2041593863 @default.
- W4253701173 cites W2048394663 @default.
- W4253701173 cites W2060022664 @default.
- W4253701173 cites W2065664528 @default.
- W4253701173 cites W2097186155 @default.
- W4253701173 cites W2104600258 @default.
- W4253701173 cites W2125663031 @default.
- W4253701173 cites W2136935607 @default.
- W4253701173 cites W2144873133 @default.
- W4253701173 cites W2156392588 @default.
- W4253701173 cites W2239756921 @default.
- W4253701173 cites W2263462535 @default.
- W4253701173 cites W2312496963 @default.
- W4253701173 cites W2315874011 @default.
- W4253701173 cites W2317417725 @default.
- W4253701173 cites W2331452414 @default.
- W4253701173 cites W2332524421 @default.
- W4253701173 cites W2334068183 @default.
- W4253701173 cites W2339587248 @default.
- W4253701173 cites W2472128056 @default.
- W4253701173 cites W2473529372 @default.
- W4253701173 cites W2474636962 @default.
- W4253701173 cites W2476721801 @default.
- W4253701173 cites W2499159979 @default.
- W4253701173 cites W2502936635 @default.
- W4253701173 cites W2514166631 @default.
- W4253701173 cites W2519150878 @default.
- W4253701173 cites W2538778544 @default.
- W4253701173 cites W2557747788 @default.
- W4253701173 cites W2573219864 @default.
- W4253701173 cites W2587649655 @default.
- W4253701173 cites W2606011273 @default.
- W4253701173 cites W2735507220 @default.
- W4253701173 cites W2769176777 @default.
- W4253701173 cites W2772584300 @default.
- W4253701173 cites W2792793744 @default.
- W4253701173 cites W2805910405 @default.
- W4253701173 cites W2886179501 @default.
- W4253701173 cites W4243074732 @default.
- W4253701173 cites W4244718249 @default.
- W4253701173 cites W4251111126 @default.
- W4253701173 cites W4251221067 @default.
- W4253701173 cites W4251349471 @default.
- W4253701173 cites W4252161483 @default.
- W4253701173 cites W4253895326 @default.
- W4253701173 cites W4254689880 @default.
- W4253701173 cites W4255544878 @default.
- W4253701173 cites W4255964564 @default.
- W4253701173 doi "https://doi.org/10.1002/ange.201807953" @default.
- W4253701173 hasPublicationYear "2018" @default.
- W4253701173 type Work @default.
- W4253701173 citedByCount "24" @default.
- W4253701173 countsByYear W42537011732019 @default.
- W4253701173 countsByYear W42537011732020 @default.
- W4253701173 countsByYear W42537011732021 @default.
- W4253701173 countsByYear W42537011732022 @default.
- W4253701173 countsByYear W42537011732023 @default.
- W4253701173 crossrefType "journal-article" @default.
- W4253701173 hasAuthorship W4253701173A5029862927 @default.
- W4253701173 hasAuthorship W4253701173A5050146687 @default.
- W4253701173 hasAuthorship W4253701173A5054485777 @default.
- W4253701173 hasAuthorship W4253701173A5071459078 @default.
- W4253701173 hasConcept C124790011 @default.
- W4253701173 hasConcept C161790260 @default.
- W4253701173 hasConcept C178790620 @default.
- W4253701173 hasConcept C185592680 @default.
- W4253701173 hasConcept C21951064 @default.
- W4253701173 hasConcept C24961977 @default.
- W4253701173 hasConcept C2777431362 @default.
- W4253701173 hasConcept C2779281246 @default.