Matches in SemOpenAlex for { <https://semopenalex.org/work/W4253710890> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4253710890 endingPage "1618" @default.
- W4253710890 startingPage "1611" @default.
- W4253710890 abstract "Analysis of DNA from 852 Island Melanesians has revealed a high frequency of single- and triple-gamma-globin genes in this population. Homozygotes for triple- and single-gamma genes have normal hematologic findings, normal hemoglobin F (HbF) levels, and when there is coexisting alpha thalassemia, appropriate levels of Bart's Hb (gamma 4) at birth. In addition, we have identified an individual with a quadruple-gamma gene chromosome who also has a normal HbF level. All single-gamma genes were A gamma, all triple-gamma genes G gamma G gamma A gamma, and the quadruple-gamma gene G gamma G gamma G gamma A gamma. Analysis of G gamma:A gamma ratios in cord bloods and HbF levels in adults showed that these additional gamma genes are expressed and are down regulated appropriately by the fetal to adult Hb switch. Analysis of the restriction enzyme haplotypes of these various chromosomes indicates that intrachromosomal cross-overs are more likely to have produced these variants than interchromosomal recombination events." @default.
- W4253710890 created "2022-05-12" @default.
- W4253710890 creator A5015216168 @default.
- W4253710890 creator A5052633635 @default.
- W4253710890 creator A5052970178 @default.
- W4253710890 creator A5055738867 @default.
- W4253710890 date "1986-06-01" @default.
- W4253710890 modified "2023-09-30" @default.
- W4253710890 title "Chromosomes with one, two, three, and four fetal globin genes: molecular and hematologic analysis" @default.
- W4253710890 doi "https://doi.org/10.1182/blood.v67.6.1611.bloodjournal6761611" @default.
- W4253710890 hasPublicationYear "1986" @default.
- W4253710890 type Work @default.
- W4253710890 citedByCount "0" @default.
- W4253710890 crossrefType "journal-article" @default.
- W4253710890 hasAuthorship W4253710890A5015216168 @default.
- W4253710890 hasAuthorship W4253710890A5052633635 @default.
- W4253710890 hasAuthorship W4253710890A5052970178 @default.
- W4253710890 hasAuthorship W4253710890A5055738867 @default.
- W4253710890 hasBestOaLocation W42537108901 @default.
- W4253710890 hasConcept C104317684 @default.
- W4253710890 hasConcept C125996951 @default.
- W4253710890 hasConcept C128319531 @default.
- W4253710890 hasConcept C153911025 @default.
- W4253710890 hasConcept C159654299 @default.
- W4253710890 hasConcept C172680121 @default.
- W4253710890 hasConcept C2776317666 @default.
- W4253710890 hasConcept C2779234561 @default.
- W4253710890 hasConcept C2908647359 @default.
- W4253710890 hasConcept C54355233 @default.
- W4253710890 hasConcept C71924100 @default.
- W4253710890 hasConcept C79162176 @default.
- W4253710890 hasConcept C86803240 @default.
- W4253710890 hasConcept C99454951 @default.
- W4253710890 hasConceptScore W4253710890C104317684 @default.
- W4253710890 hasConceptScore W4253710890C125996951 @default.
- W4253710890 hasConceptScore W4253710890C128319531 @default.
- W4253710890 hasConceptScore W4253710890C153911025 @default.
- W4253710890 hasConceptScore W4253710890C159654299 @default.
- W4253710890 hasConceptScore W4253710890C172680121 @default.
- W4253710890 hasConceptScore W4253710890C2776317666 @default.
- W4253710890 hasConceptScore W4253710890C2779234561 @default.
- W4253710890 hasConceptScore W4253710890C2908647359 @default.
- W4253710890 hasConceptScore W4253710890C54355233 @default.
- W4253710890 hasConceptScore W4253710890C71924100 @default.
- W4253710890 hasConceptScore W4253710890C79162176 @default.
- W4253710890 hasConceptScore W4253710890C86803240 @default.
- W4253710890 hasConceptScore W4253710890C99454951 @default.
- W4253710890 hasIssue "6" @default.
- W4253710890 hasLocation W42537108901 @default.
- W4253710890 hasOpenAccess W4253710890 @default.
- W4253710890 hasPrimaryLocation W42537108901 @default.
- W4253710890 hasRelatedWork W1037649 @default.
- W4253710890 hasRelatedWork W13894564 @default.
- W4253710890 hasRelatedWork W25725819 @default.
- W4253710890 hasRelatedWork W2686235 @default.
- W4253710890 hasRelatedWork W32731710 @default.
- W4253710890 hasRelatedWork W38747043 @default.
- W4253710890 hasRelatedWork W408241 @default.
- W4253710890 hasRelatedWork W44388856 @default.
- W4253710890 hasRelatedWork W4564883 @default.
- W4253710890 hasRelatedWork W8353607 @default.
- W4253710890 hasVolume "67" @default.
- W4253710890 isParatext "false" @default.
- W4253710890 isRetracted "false" @default.
- W4253710890 workType "article" @default.