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• W4253717030 abstract "Diffuse panbronchiolitis (DPB) is a type of chronic bronchiolitis characterized by chronic cough, copious sputum, and exertional dyspnea, with bilateral small nodular shadows often associated with hyperinflation of the lungs, seen on chest x-ray films. It is a disease that has received attention in Japan since the late 1960s and studies on DPB have been promoted by the financial support from the Ministry of Health and Welfare of Japan. Pathologically, the diagnosis of the disease is made when (1) the chronic inflammatory airways disease affects bilateral lung diffusely, (2) chronic inflammation occurs mainly in the bronchiolar wall and the central parts of lobules, and (3) foamy cells accumulate in the wall of respiratory bronchioles, and adjacent alveolar ducts, and alveoli with infiltration of lymphoid cells. Although the diagnosis is made usually on the basis of the clinical findings, it has been confirmed recently by us, through the histopathologic study of open lung biopsy specimens from the cases with clinically diagnosis of DPB, that clinical DPB cases include cases with not only pathologic DPB, but also unclassified bronchiolitis and bronchiolectasis.While DPB is a rare disease outside Japan, we have confirmed cases identical to Japanese DPB, clinically and histologically, in Seoul, Taipei, Hersey and Bologna.Diffuse panbronchiolitis is a chronic infectious disease of the lower respiratory tract, as well as an obstructive airway disease. Although many kinds of antibiotics have been used in its treatment, DPB has been considered a progressive disease. A revolutionary advance was made in the treatment of clinical DPB since the report in 1987 by Kudoh et al1Kudoh S Uetake T Hagiwara K Hirayama M Hus LH Kimura H et al.Jpn J Thorac Dis. 1987; 25 (in Japanese): 632-642Google Scholar that low dose (400-600 mg/day) long-term (at least four weeks) administration of erythromycin is effective for clinical DPB. At this dosage, erythromycin cannot be expected to act as an antibactericidal agent. Its antiinflammatory action is not clear and so far details of the effects of erythromycin on the pathophysiology of DPB remains to be investigated.Diffuse bronchiectasis and cystic fibrosis are understood to be disorders similar to DPB, at least clinically. For the clinical and pathophysiologic comparative studies of the three disorders and discussions on the erythromycin treatment of DPB, we are planning to have two meetings on September 11, 1991 in Kyoto: “DPB, diffuse bronchiectasis, and cystic fibrosis” and “Why is erythromycin effective to DPB?” The meetings are to be held at satellite symposia during the XII World Congress on Sarcoidosis and Other Granulomatous Disorders. Diffuse panbronchiolitis (DPB) is a type of chronic bronchiolitis characterized by chronic cough, copious sputum, and exertional dyspnea, with bilateral small nodular shadows often associated with hyperinflation of the lungs, seen on chest x-ray films. It is a disease that has received attention in Japan since the late 1960s and studies on DPB have been promoted by the financial support from the Ministry of Health and Welfare of Japan. Pathologically, the diagnosis of the disease is made when (1) the chronic inflammatory airways disease affects bilateral lung diffusely, (2) chronic inflammation occurs mainly in the bronchiolar wall and the central parts of lobules, and (3) foamy cells accumulate in the wall of respiratory bronchioles, and adjacent alveolar ducts, and alveoli with infiltration of lymphoid cells. Although the diagnosis is made usually on the basis of the clinical findings, it has been confirmed recently by us, through the histopathologic study of open lung biopsy specimens from the cases with clinically diagnosis of DPB, that clinical DPB cases include cases with not only pathologic DPB, but also unclassified bronchiolitis and bronchiolectasis. While DPB is a rare disease outside Japan, we have confirmed cases identical to Japanese DPB, clinically and histologically, in Seoul, Taipei, Hersey and Bologna. Diffuse panbronchiolitis is a chronic infectious disease of the lower respiratory tract, as well as an obstructive airway disease. Although many kinds of antibiotics have been used in its treatment, DPB has been considered a progressive disease. A revolutionary advance was made in the treatment of clinical DPB since the report in 1987 by Kudoh et al1Kudoh S Uetake T Hagiwara K Hirayama M Hus LH Kimura H et al.Jpn J Thorac Dis. 1987; 25 (in Japanese): 632-642Google Scholar that low dose (400-600 mg/day) long-term (at least four weeks) administration of erythromycin is effective for clinical DPB. At this dosage, erythromycin cannot be expected to act as an antibactericidal agent. Its antiinflammatory action is not clear and so far details of the effects of erythromycin on the pathophysiology of DPB remains to be investigated. Diffuse bronchiectasis and cystic fibrosis are understood to be disorders similar to DPB, at least clinically. For the clinical and pathophysiologic comparative studies of the three disorders and discussions on the erythromycin treatment of DPB, we are planning to have two meetings on September 11, 1991 in Kyoto: “DPB, diffuse bronchiectasis, and cystic fibrosis” and “Why is erythromycin effective to DPB?” The meetings are to be held at satellite symposia during the XII World Congress on Sarcoidosis and Other Granulomatous Disorders." @default.
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• W4253717030 date "1991-09-01" @default.
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• W4253717030 title "Diffuse Panbronchiolitis" @default.
• W4253717030 doi "https://doi.org/10.1378/chest.100.3.596" @default.
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