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• W4253720935 abstract "Pre-eclampsia is associated with deficient intravascular production of prostacyclin, a vasodilator, and excessive production of thromboxane, a platelet-derived vasoconstrictor and stimulant of platelet aggregation. These observations led to the hypotheses that antiplatelet agents, low-dose aspirin in particular, might prevent or delay the development of pre-eclampsia.To assess the effectiveness and safety of antiplatelet agents when given to women at risk of developing pre-eclampsia.We searched the Cochrane Pregnancy and Childbirth Group trials register (September 2003), the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 2, 2003), EMBASE (1994 to 2003) and we handsearched the congress proceedings of the International and European Societies for the Study of Hypertension in Pregnancy.All randomised trials comparing antiplatelet agents with either placebo or no antiplatelet agent during pregnancy. Quasi-random study designs were excluded. Participants were pregnant women considered to be at risk of developing pre-eclampsia. Interventions were any comparisons of an antiplatelet agent (such as low-dose aspirin or dipyridamole) with either placebo or no antiplatelet agent.Two reviewers assessed trials for inclusion in the review and extracted data. We entered data into the Review Manager software and double checked.Fifty-one trials involving 36,500 women are included in this review. There is a 19% reduction in the risk of pre-eclampsia associated with the use of antiplatelet agents ((43 trials, 33,439 women; relative risk (RR) 0.81, 95% confidence interval (CI) 0.75 to 0.88); number needed to treat (NNT) 69 (51, 109)).Twenty-eight trials (31,845 women) reported preterm birth. There is a small (7%) reduction in the risk of delivery before 37 completed weeks ((RR 0.93, 95% CI 0.89 to 0.98); NNT 83 (50, 238)). Fetal or neonatal deaths were reported in 38 trials (34,010 women). Overall there is a 16% reduction in baby deaths in the antiplatelet group (RR 0.84, 95% CI 0.74 to 0.96); NNT 227 (128, 909)). Small-for-gestational age babies were reported in 32 trials (24,310 women), with an 8% reduction in risk (RR 0.92, 95% CI 0.85 to 1.00). There were no significant differences between treatment and control groups in any other measures of outcome.Antiplatelet agents, in this review largely low-dose aspirin, have small-moderate benefits when used for prevention of pre-eclampsia. Further information is required to assess which women are most likely to benefit, when treatment is best started, and at what dose." @default.
• W4253720935 created "2022-05-12" @default.
• W4253720935 creator A5001657958 @default.
• W4253720935 creator A5066267283 @default.
• W4253720935 creator A5067179548 @default.
• W4253720935 creator A5091627888 @default.
• W4253720935 date "2003-10-20" @default.
• W4253720935 modified "2023-10-11" @default.
• W4253720935 title "Antiplatelet agents for preventing pre-eclampsia and its complications" @default.
• W4253720935 cites W1535469484 @default.
• W4253720935 cites W1550696843 @default.
• W4253720935 cites W172038636 @default.
• W4253720935 cites W1844917530 @default.
• W4253720935 cites W1972909175 @default.
• W4253720935 cites W1973459042 @default.
• W4253720935 cites W1975213945 @default.
• W4253720935 cites W1978635975 @default.
• W4253720935 cites W1983144487 @default.
• W4253720935 cites W1983429038 @default.
• W4253720935 cites W1985122146 @default.
• W4253720935 cites W1985793416 @default.
• W4253720935 cites W1988433564 @default.
• W4253720935 cites W1989170382 @default.
• W4253720935 cites W1991627561 @default.
• W4253720935 cites W1993923446 @default.
• W4253720935 cites W1994779418 @default.
• W4253720935 cites W1995613614 @default.
• W4253720935 cites W1998051507 @default.
• W4253720935 cites W1999644742 @default.
• W4253720935 cites W2000135242 @default.
• W4253720935 cites W2001248679 @default.
• W4253720935 cites W2001340498 @default.
• W4253720935 cites W2001663268 @default.
• W4253720935 cites W2002269694 @default.
• W4253720935 cites W2006695727 @default.
• W4253720935 cites W2008256216 @default.
• W4253720935 cites W2009813800 @default.
• W4253720935 cites W2010005098 @default.
• W4253720935 cites W2011341529 @default.
• W4253720935 cites W2013557422 @default.
• W4253720935 cites W2014694623 @default.
• W4253720935 cites W2014753688 @default.
• W4253720935 cites W2015309500 @default.
• W4253720935 cites W2017294539 @default.
• W4253720935 cites W2021879241 @default.
• W4253720935 cites W2022461235 @default.
• W4253720935 cites W2025779964 @default.
• W4253720935 cites W2025950811 @default.
• W4253720935 cites W2026107303 @default.
• W4253720935 cites W2026307867 @default.
• W4253720935 cites W2029013982 @default.
• W4253720935 cites W2032748237 @default.
• W4253720935 cites W2035223305 @default.
• W4253720935 cites W2037966828 @default.
• W4253720935 cites W2038648562 @default.
• W4253720935 cites W2039790361 @default.
• W4253720935 cites W2040205966 @default.
• W4253720935 cites W2044192971 @default.
• W4253720935 cites W2045654116 @default.
• W4253720935 cites W2048260363 @default.
• W4253720935 cites W2049435009 @default.
• W4253720935 cites W2049556573 @default.
• W4253720935 cites W2049576998 @default.
• W4253720935 cites W2049735542 @default.
• W4253720935 cites W2052081106 @default.
• W4253720935 cites W2053397656 @default.
• W4253720935 cites W2055507321 @default.
• W4253720935 cites W2059071457 @default.
• W4253720935 cites W2067447331 @default.
• W4253720935 cites W2070145124 @default.
• W4253720935 cites W2073004442 @default.
• W4253720935 cites W2075984493 @default.
• W4253720935 cites W2077418937 @default.
• W4253720935 cites W2079302074 @default.
• W4253720935 cites W2080780491 @default.
• W4253720935 cites W2082099523 @default.
• W4253720935 cites W2083348649 @default.
• W4253720935 cites W2083571158 @default.
• W4253720935 cites W2085287091 @default.
• W4253720935 cites W2086358124 @default.
• W4253720935 cites W2091755086 @default.
• W4253720935 cites W2092021592 @default.
• W4253720935 cites W2092632618 @default.
• W4253720935 cites W2095470682 @default.
• W4253720935 cites W2100267675 @default.
• W4253720935 cites W2100426281 @default.
• W4253720935 cites W2102939691 @default.
• W4253720935 cites W2110379798 @default.
• W4253720935 cites W2112422400 @default.
• W4253720935 cites W2116316298 @default.
• W4253720935 cites W2120306786 @default.
• W4253720935 cites W2124907856 @default.
• W4253720935 cites W2131925540 @default.
• W4253720935 cites W2133479239 @default.
• W4253720935 cites W2160084743 @default.
• W4253720935 cites W2171003562 @default.
• W4253720935 cites W2175326739 @default.
• W4253720935 cites W2176371201 @default.
• W4253720935 cites W2332128238 @default.
• W4253720935 cites W2340870097 @default.

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