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- W4253732569 abstract "Abstract Background Orthostatic hypotension (OH) is common in Parkinson disease (PD) and often coincident with cognitive impairment. The locus coeruleus (LC), a central autonomic and cognitive regulator, may be a common pathophysiologic link. Here we tested whether LC structural pathology, measured by neuromelanin-sensitive MRI, is associated with OH, cognition, and OH symptom presence (OHSx) in PD. Methods PD motor exam, orthostatic vital signs (OVS), and depression, anxiety, and fatigue symptom scales were measured in 62 patients. Automated segmentation of LC and substantia nigra pars compacta (SNc, control region) took place using 3T MRI-based 2D T1-weighted and neuromelanin-sensitive sequences. LC/SNc volumes (mm 3 ) were compared between OH and no-OH patients (N=9 & 53) using MACOVA. One-tailed partial correlations (False discovery rate (FDR) corrected) between LC volume, OVS, and MoCA were measured. MANOVA tested for relationships between OHSx, LC/SNc volumes, OVS, and non-motor scales. Results LC, but not SNc, volumes were reduced in OH-patients, compared to no-OH (LC p=0.01; SNc p=0.44). LC volumes correlated with OVS (systolic blood pressure/SBP r=0.24, p FDR =0.043; diastolic/DBP r=0.25, p FDR =0.043; heart rate/HR r=-0.32, p FDR =0.024) and with MoCA (r=0.22, p FDR =0.043). OH-patients were more likely to endorse OHSx (Chi Sq. p=0.047). LC/SNc volumes were unrelated to OHSx but were associated with DBP change (F=4.3, p=0.043; SBP trended – F=3.8, p=0.055), and with greater depressive (F=6.6, p=0.012) and fatigue (F=5.13, p=0.027) symptoms. Conclusions This study supports LC as a neural substrate for OH and possibly cognitive decline in PD, but not OHSx, which were more associated with depressive and fatigue symptoms. A larger cohort of OH-patients is needed to validate these findings." @default.
- W4253732569 created "2022-05-12" @default.
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- W4253732569 date "2021-10-11" @default.
- W4253732569 modified "2023-10-18" @default.
- W4253732569 title "Locus Coeruleus Volume is Reduced in Early Parkinson Disease-Related Orthostatic Hypotension." @default.
- W4253732569 doi "https://doi.org/10.21203/rs.3.rs-936643/v1" @default.
- W4253732569 hasPublicationYear "2021" @default.
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