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- W4253737171 abstract "Abstract Controlled protein assembly provides a means to regulate function. Supramolecular building blocks, including rigid macrocycles, are versatile triggers of protein assembly. Now it is shown that sulfonato‐calix[8]arene ( sclx 8 ) mediates the formation of cytochrome c tetramers in solution. This tetramer spontaneously disassembles at ≥2 equivalents of sclx 8 , providing a remarkable example of auto‐regulation. Using X‐ray crystallography the sclx 8 binding sites on cytochrome c were characterized. Crystal structures at different protein–ligand ratios reveal varying degrees (up to 35 %) of protein surface coverage by the flexible calixarene and suggest a mechanism for oligomer disassembly. The solution structure of the oligomer was characterized by small‐angle X‐ray scattering. Overall, the data indicate calixarene‐controlled protein assembly and disassembly without the requirement for a competitive inhibitor, and point to protein encapsulation by a flexible macrocycle." @default.
- W4253737171 created "2022-05-12" @default.
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- W4253737171 date "2018-09-12" @default.
- W4253737171 modified "2023-10-13" @default.
- W4253737171 title "Auto‐regulated Protein Assembly on a Supramolecular Scaffold" @default.
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- W4253737171 doi "https://doi.org/10.1002/ange.201807490" @default.
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