Matches in SemOpenAlex for { <https://semopenalex.org/work/W4253745404> ?p ?o ?g. }
- W4253745404 endingPage "1265" @default.
- W4253745404 startingPage "1257" @default.
- W4253745404 abstract "A major site of DNA bending is located 1.6 kb upstream of the P1 transcription start site of the human c-myc gene, near the center of a reported zone of initiation of DNA replication. A repeated, purine-rich element, termed PUR, at the bend site is specifically bound by a protein in HeLa cell nuclear extracts. This protein has specific affinity for the purine-rich single strand of the element. Methylation interference maps a pattern of specific contact points with guanosine bases in a 24-mer oligonucleotide containing the element. UV cross-linking reveals that contact is made by a polypeptide of approximately 28 kDa. The PUR element is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. The consensus sequence GGNNGAGGGAGARRRR has been derived. This element is present near centers of regions of two mammalian loci (human c-myc and hamster dhfr) recently reported as initiation zones for DNA replication. A 24-mer oligonucleotide representing the hamster dhfr version of the PUR element effectively competes with the human c-myc version for binding to Pur." @default.
- W4253745404 created "2022-05-12" @default.
- W4253745404 creator A5042577601 @default.
- W4253745404 creator A5084141911 @default.
- W4253745404 date "1992-03-01" @default.
- W4253745404 modified "2023-10-17" @default.
- W4253745404 title "The HeLa Pur factor binds single-stranded DNA at a specific element conserved in gene flanking regions and origins of DNA replication" @default.
- W4253745404 cites W1558516755 @default.
- W4253745404 cites W1964262489 @default.
- W4253745404 cites W1967427366 @default.
- W4253745404 cites W1967932844 @default.
- W4253745404 cites W1977751950 @default.
- W4253745404 cites W1978853657 @default.
- W4253745404 cites W1990731600 @default.
- W4253745404 cites W1991826157 @default.
- W4253745404 cites W1993243592 @default.
- W4253745404 cites W1994038589 @default.
- W4253745404 cites W1997986439 @default.
- W4253745404 cites W1998058932 @default.
- W4253745404 cites W2001725306 @default.
- W4253745404 cites W2009230618 @default.
- W4253745404 cites W2014141253 @default.
- W4253745404 cites W2015249727 @default.
- W4253745404 cites W2030663089 @default.
- W4253745404 cites W2031408368 @default.
- W4253745404 cites W2033706348 @default.
- W4253745404 cites W2038874225 @default.
- W4253745404 cites W2041031381 @default.
- W4253745404 cites W2041401543 @default.
- W4253745404 cites W2043592675 @default.
- W4253745404 cites W2044060614 @default.
- W4253745404 cites W2053285252 @default.
- W4253745404 cites W2060230514 @default.
- W4253745404 cites W2063443838 @default.
- W4253745404 cites W2077790814 @default.
- W4253745404 cites W2079078652 @default.
- W4253745404 cites W2080835352 @default.
- W4253745404 cites W2082534786 @default.
- W4253745404 cites W2084874442 @default.
- W4253745404 cites W2088701644 @default.
- W4253745404 cites W2090081894 @default.
- W4253745404 cites W2092769914 @default.
- W4253745404 cites W2101448549 @default.
- W4253745404 cites W2128569886 @default.
- W4253745404 cites W2169595922 @default.
- W4253745404 cites W2172096382 @default.
- W4253745404 cites W2173708640 @default.
- W4253745404 cites W4233304227 @default.
- W4253745404 doi "https://doi.org/10.1128/mcb.12.3.1257-1265.1992" @default.
- W4253745404 hasPublicationYear "1992" @default.
- W4253745404 type Work @default.
- W4253745404 citedByCount "3" @default.
- W4253745404 crossrefType "journal-article" @default.
- W4253745404 hasAuthorship W4253745404A5042577601 @default.
- W4253745404 hasAuthorship W4253745404A5084141911 @default.
- W4253745404 hasConcept C101762097 @default.
- W4253745404 hasConcept C104317684 @default.
- W4253745404 hasConcept C129312508 @default.
- W4253745404 hasConcept C132376346 @default.
- W4253745404 hasConcept C150194340 @default.
- W4253745404 hasConcept C151158763 @default.
- W4253745404 hasConcept C153911025 @default.
- W4253745404 hasConcept C54355233 @default.
- W4253745404 hasConcept C552990157 @default.
- W4253745404 hasConcept C58337764 @default.
- W4253745404 hasConcept C73573662 @default.
- W4253745404 hasConcept C86803240 @default.
- W4253745404 hasConcept C98086919 @default.
- W4253745404 hasConceptScore W4253745404C101762097 @default.
- W4253745404 hasConceptScore W4253745404C104317684 @default.
- W4253745404 hasConceptScore W4253745404C129312508 @default.
- W4253745404 hasConceptScore W4253745404C132376346 @default.
- W4253745404 hasConceptScore W4253745404C150194340 @default.
- W4253745404 hasConceptScore W4253745404C151158763 @default.
- W4253745404 hasConceptScore W4253745404C153911025 @default.
- W4253745404 hasConceptScore W4253745404C54355233 @default.
- W4253745404 hasConceptScore W4253745404C552990157 @default.
- W4253745404 hasConceptScore W4253745404C58337764 @default.
- W4253745404 hasConceptScore W4253745404C73573662 @default.
- W4253745404 hasConceptScore W4253745404C86803240 @default.
- W4253745404 hasConceptScore W4253745404C98086919 @default.
- W4253745404 hasIssue "3" @default.
- W4253745404 hasLocation W42537454041 @default.
- W4253745404 hasOpenAccess W4253745404 @default.
- W4253745404 hasPrimaryLocation W42537454041 @default.
- W4253745404 hasRelatedWork W178883812 @default.
- W4253745404 hasRelatedWork W1855876669 @default.
- W4253745404 hasRelatedWork W1886437606 @default.
- W4253745404 hasRelatedWork W1917685925 @default.
- W4253745404 hasRelatedWork W2005705565 @default.
- W4253745404 hasRelatedWork W2024499420 @default.
- W4253745404 hasRelatedWork W2028039977 @default.
- W4253745404 hasRelatedWork W2099783021 @default.
- W4253745404 hasRelatedWork W4251386472 @default.
- W4253745404 hasRelatedWork W56886447 @default.
- W4253745404 hasVolume "12" @default.
- W4253745404 isParatext "false" @default.
- W4253745404 isRetracted "false" @default.