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- W4253755364 abstract "Vascular cell adhesion molecule 1 (VCAM-1) is an important inflammatory biomarker correlating with retinal disease progression. Thus, detection of VCAM-1 mRNA expression levels at an early disease stage could be an important predictive biomarker to assess the risk of disease progression and monitoring treatment response. We have developed VCAM-1 targeted antisense hairpin DNA-functionalized gold nanoparticles (AS-VCAM-1 hAuNP) for the real time detection of VCAM-1 mRNA expression levels in retinal endothelial cells. The AS-VCAM-1 hAuNP fluorescence enhancement clearly visualized the TNF-α induced cellular VCAM-1 mRNA levels with high signal to noise ratios compared to normal serum treated cells. The scrambled hAuNP probes were minimally detectable under same image acquisition conditions. Intracellular hAuNPs were detected using transmission electron microscopy (TEM) analysis of the intact cells. In addition, the AS-VCAM-1 hAuNP probes exhibited no acute toxicity to the retinal microvascular endothelial cells as measured by live-dead assay." @default.
- W4253755364 created "2022-05-12" @default.
- W4253755364 date "2017-04-01" @default.
- W4253755364 modified "2023-09-25" @default.
- W4253755364 title "Surveillance-Optimierung durch strukturierte Surveillance-Berichte, Normierungen und regionale Vergleiche: ein Erfahrungsbericht aus Mecklenburg-Vorpommern" @default.
- W4253755364 doi "https://doi.org/10.1016/j.khinf.2017.03.005" @default.
- W4253755364 hasPublicationYear "2017" @default.
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