Matches in SemOpenAlex for { <https://semopenalex.org/work/W4253785904> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4253785904 abstract "Increasing studies have suggested that the renal proximal tubule is a site of injury in diabetic nephropathy (DN), and progressive renal tubulointerstitial fibrosis is an important mediator of progressive kidney dysfunction in DN. In this study, we observed increased expression and activation of YAP (Yes-associated protein) in renal proximal tubule epithelial cells (RPTC) in diabetic patient and mouse kidneys. Inducible deletion of <i>Yap</i> specifically in RPTC or administration of the YAP inhibitor verteporfin significantly attenuated diabetic tubulointerstitial fibrosis. EGFR-dependent activation of RhoA/Rock and PI3K-Akt signals and their reciprocal interaction were upstream of proximal tubule YAP activation in diabetic kidneys. Production and release of CTGF in culture medium were significantly augmented in HEK293 transfected with a constitutively active YAP mutant, and the conditioned medium collected from these cells activated and transduced fibroblasts into myofibroblasts. This study demonstrates that proximal tubule YAP dependent paracrine mechanisms play an important role in diabetic interstitial fibrogenesis; therefore, targeting Hippo signaling may be a therapeutic strategy to prevent the development and progression of diabetic interstitial fibrogenesis." @default.
- W4253785904 created "2022-05-12" @default.
- W4253785904 creator A5006593165 @default.
- W4253785904 creator A5017527567 @default.
- W4253785904 creator A5019544133 @default.
- W4253785904 creator A5031318134 @default.
- W4253785904 creator A5039761725 @default.
- W4253785904 creator A5052123970 @default.
- W4253785904 creator A5066303625 @default.
- W4253785904 creator A5072186094 @default.
- W4253785904 date "2020-08-25" @default.
- W4253785904 modified "2023-09-26" @default.
- W4253785904 title "YAP Activation in Renal Proximal Tubule Cells Drives Diabetic Renal Interstitial Fibrogenesis" @default.
- W4253785904 doi "https://doi.org/10.2337/figshare.12808352" @default.
- W4253785904 hasPublicationYear "2020" @default.
- W4253785904 type Work @default.
- W4253785904 citedByCount "0" @default.
- W4253785904 crossrefType "posted-content" @default.
- W4253785904 hasAuthorship W4253785904A5006593165 @default.
- W4253785904 hasAuthorship W4253785904A5017527567 @default.
- W4253785904 hasAuthorship W4253785904A5019544133 @default.
- W4253785904 hasAuthorship W4253785904A5031318134 @default.
- W4253785904 hasAuthorship W4253785904A5039761725 @default.
- W4253785904 hasAuthorship W4253785904A5052123970 @default.
- W4253785904 hasAuthorship W4253785904A5066303625 @default.
- W4253785904 hasAuthorship W4253785904A5072186094 @default.
- W4253785904 hasBestOaLocation W42537859041 @default.
- W4253785904 hasConcept C126322002 @default.
- W4253785904 hasConcept C134018914 @default.
- W4253785904 hasConcept C170493617 @default.
- W4253785904 hasConcept C185592680 @default.
- W4253785904 hasConcept C207865475 @default.
- W4253785904 hasConcept C2775960820 @default.
- W4253785904 hasConcept C2777093181 @default.
- W4253785904 hasConcept C2779922275 @default.
- W4253785904 hasConcept C2780091579 @default.
- W4253785904 hasConcept C2780559512 @default.
- W4253785904 hasConcept C2780631158 @default.
- W4253785904 hasConcept C502942594 @default.
- W4253785904 hasConcept C62478195 @default.
- W4253785904 hasConcept C71924100 @default.
- W4253785904 hasConcept C7876069 @default.
- W4253785904 hasConcept C86554907 @default.
- W4253785904 hasConcept C86803240 @default.
- W4253785904 hasConcept C95444343 @default.
- W4253785904 hasConceptScore W4253785904C126322002 @default.
- W4253785904 hasConceptScore W4253785904C134018914 @default.
- W4253785904 hasConceptScore W4253785904C170493617 @default.
- W4253785904 hasConceptScore W4253785904C185592680 @default.
- W4253785904 hasConceptScore W4253785904C207865475 @default.
- W4253785904 hasConceptScore W4253785904C2775960820 @default.
- W4253785904 hasConceptScore W4253785904C2777093181 @default.
- W4253785904 hasConceptScore W4253785904C2779922275 @default.
- W4253785904 hasConceptScore W4253785904C2780091579 @default.
- W4253785904 hasConceptScore W4253785904C2780559512 @default.
- W4253785904 hasConceptScore W4253785904C2780631158 @default.
- W4253785904 hasConceptScore W4253785904C502942594 @default.
- W4253785904 hasConceptScore W4253785904C62478195 @default.
- W4253785904 hasConceptScore W4253785904C71924100 @default.
- W4253785904 hasConceptScore W4253785904C7876069 @default.
- W4253785904 hasConceptScore W4253785904C86554907 @default.
- W4253785904 hasConceptScore W4253785904C86803240 @default.
- W4253785904 hasConceptScore W4253785904C95444343 @default.
- W4253785904 hasLocation W42537859041 @default.
- W4253785904 hasLocation W42537859042 @default.
- W4253785904 hasLocation W42537859043 @default.
- W4253785904 hasOpenAccess W4253785904 @default.
- W4253785904 hasPrimaryLocation W42537859041 @default.
- W4253785904 hasRelatedWork W1894266 @default.
- W4253785904 hasRelatedWork W295232 @default.
- W4253785904 hasRelatedWork W3156605 @default.
- W4253785904 hasRelatedWork W6478985 @default.
- W4253785904 hasRelatedWork W721785 @default.
- W4253785904 hasRelatedWork W7839633 @default.
- W4253785904 hasRelatedWork W8050865 @default.
- W4253785904 hasRelatedWork W8440890 @default.
- W4253785904 hasRelatedWork W8865407 @default.
- W4253785904 hasRelatedWork W1716257 @default.
- W4253785904 isParatext "false" @default.
- W4253785904 isRetracted "false" @default.
- W4253785904 workType "article" @default.