FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4253844036> ?p ?o ?g. }

• W4253844036 endingPage "287" @default.
• W4253844036 startingPage "287" @default.
• W4253844036 abstract "We thank Dr Vanderhelst and colleagues for their interest in our manuscript [[1]Welsh L. Nesci C. Tran H. Tomai M. Ranganathan S. Lung clearance index during hospital admission in school-age children with cystic fibrosis.J Cyst Fibros. 2014; ([Electronic publication ahead of print])Abstract Full Text Full Text PDF Scopus (17) Google Scholar]. However, the data they have provided does not convince us to change our position with regard to the use of multiple breath washout (MBW) to assess intravenous (IV) antibiotic treatment response during pulmonary exacerbation in children with cystic fibrosis (CF) [[2]Vanderhelst E. De Meirleir L. Schuermans D. Malfroot A. Vincken W. Verbanck S. Evidence of an acinar response following treatment for exacerbation in adult patients with cystic fibrosis.Respiration. 2014; 87: 492-498Crossref PubMed Scopus (10) Google Scholar]. Indeed, it further highlights the heterogeneous nature of MBW outcomes in this disease group. Over 50% of their study patients did not have an improvement in lung clearance index (LCI) and this is in keeping with a growing list of similar studies that have included a wide range of ages and disease severity [3Horsley A.R. Davies J.C. Gray R.D. Macleod K.A. Donovan J. Aziz Z.A. Bell N.J. Rainer M. Mt-Isa S. Voase N. Dewar M.H. Saunders C. Gibson J.S. Parra-Leiton J. Larsen M.D. Jeswiet S. Soussi S. Bakar Y. Meister M.G. Tyler P. Doherty A. Hansell D.M. Ashby D. Hyde S.C. Gill D.R. Greening A.P. Porteous D.J. Innes J.A. Boyd A.C. Griesenbach U. Cunningham S. Alton E.W. Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation.Thorax. 2013; 68: 532-539Crossref PubMed Scopus (109) Google Scholar, 4Robinson P.D. Cooper P. Van Asperen P. Fitzgerald D. Selvadurai H. Using index of ventilation to assess response to treatment for acute pulmonary exacerbation in children with cystic fibrosis.Pediatr Pulmonol. 2009; 44: 733-742Crossref PubMed Scopus (56) Google Scholar, 5Yammine S. Bigler A. Casaulta C. Singer F. Latzin P. Reasons for heterogeneous change in LCI in children with cystic fibrosis after antibiotic treatment.Thorax. 2014; 69: 183Crossref PubMed Scopus (20) Google Scholar]. Importantly though, the MBW measurements in the Vanderhelst study were performed after the administration of 400 μg bronchodilator. This deviation from the recommended guidelines [[6]Robinson P.D. Latzin P. Verbanck S. Hall G.L. Horsley A. Gappa M. Thamrin C. Arets H.G. Aurora P. Fuchs S.I. King G.G. Lum S. Macleod K. Paiva M. Pillow J.J. Ranganathan S. Ratjen F. Singer F. Sonnappa S. Stocks J. Subbarao P. Thompson B.R. Gustafsson P.M. Consensus statement for inert gas washout measurement using multiple- and single-breath tests.Eur Respir J. 2013; 41: 507-522Crossref PubMed Scopus (526) Google Scholar] not only precludes comparison with the extant literature, but also brings into question their findings. Considering the onset of action and half-life of bronchodilator, the timing of the MBW measurement following bronchodilator administration is crucial. During washout, larger breaths can lead to the release of significant amounts of trapped gas which invalidates the SnIII analysis and can also result in increased LCI values. It is feasible to suggest that additional lung units, including previously trapped gas, could be recruited as bronchodilator takes effect, and this may be ongoing throughout the testing session. Moreover, individual bronchodilator response may be different at admission compared to discharge. While we can only speculate about the degree of influence this methodology would yield, it may partly explain the acinar contribution the authors now report. Several of the aforementioned studies have reported improvements in LCI at group level, but the individual response to treatment has been noticeably variable. It therefore remains difficult to see MBW playing a useful role in such a clinical setting. We also express our concern for the extension of modelled derivations and assumptions as to what measurements made by MBW mean to interpretations of structure–function relationships in the clinical setting. Can such assumptions, for example, be relevant to the growing child, or to pre-school children during rapid lung development? We maintain that LCI should not be used to gauge the short-term clinical response to IV antibiotics in school-age children with CF. Until the data are compelling and tested in a large number of subjects of different ages, with disease of varying severity, and the findings used in the clinical setting to determine or monitor response to IV antibiotics, we question the utility of any MBW measurement in this setting." @default.
• W4253844036 created "2022-05-12" @default.
• W4253844036 creator A5012648834 @default.
• W4253844036 creator A5052211893 @default.
• W4253844036 creator A5083537871 @default.
• W4253844036 creator A5084936913 @default.
• W4253844036 creator A5089038895 @default.
• W4253844036 date "2015-03-01" @default.
• W4253844036 modified "2023-10-14" @default.
• W4253844036 title "Authors' response" @default.
• W4253844036 doi "https://doi.org/10.1016/j.jcf.2014.09.004" @default.
• W4253844036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25261347" @default.
• W4253844036 hasPublicationYear "2015" @default.
• W4253844036 type Work @default.
• W4253844036 citedByCount "0" @default.
• W4253844036 crossrefType "journal-article" @default.
• W4253844036 hasAuthorship W4253844036A5012648834 @default.
• W4253844036 hasAuthorship W4253844036A5052211893 @default.
• W4253844036 hasAuthorship W4253844036A5083537871 @default.
• W4253844036 hasAuthorship W4253844036A5084936913 @default.
• W4253844036 hasAuthorship W4253844036A5089038895 @default.
• W4253844036 hasBestOaLocation W42538440361 @default.
• W4253844036 hasConcept C126322002 @default.
• W4253844036 hasConcept C17744445 @default.
• W4253844036 hasConcept C199539241 @default.
• W4253844036 hasConcept C2776938444 @default.
• W4253844036 hasConcept C2777014857 @default.
• W4253844036 hasConcept C2777714996 @default.
• W4253844036 hasConcept C2779379686 @default.
• W4253844036 hasConcept C2779473830 @default.
• W4253844036 hasConcept C71924100 @default.
• W4253844036 hasConcept C83867959 @default.
• W4253844036 hasConcept C90924648 @default.
• W4253844036 hasConceptScore W4253844036C126322002 @default.
• W4253844036 hasConceptScore W4253844036C17744445 @default.
• W4253844036 hasConceptScore W4253844036C199539241 @default.
• W4253844036 hasConceptScore W4253844036C2776938444 @default.
• W4253844036 hasConceptScore W4253844036C2777014857 @default.
• W4253844036 hasConceptScore W4253844036C2777714996 @default.
• W4253844036 hasConceptScore W4253844036C2779379686 @default.
• W4253844036 hasConceptScore W4253844036C2779473830 @default.
• W4253844036 hasConceptScore W4253844036C71924100 @default.
• W4253844036 hasConceptScore W4253844036C83867959 @default.
• W4253844036 hasConceptScore W4253844036C90924648 @default.
• W4253844036 hasIssue "2" @default.
• W4253844036 hasLocation W42538440361 @default.
• W4253844036 hasLocation W42538440362 @default.
• W4253844036 hasOpenAccess W4253844036 @default.
• W4253844036 hasPrimaryLocation W42538440361 @default.
• W4253844036 hasRelatedWork W1970639481 @default.
• W4253844036 hasRelatedWork W2091042844 @default.
• W4253844036 hasRelatedWork W2110977151 @default.
• W4253844036 hasRelatedWork W2120066589 @default.
• W4253844036 hasRelatedWork W2286213499 @default.
• W4253844036 hasRelatedWork W2905600612 @default.
• W4253844036 hasRelatedWork W2910496400 @default.
• W4253844036 hasRelatedWork W2982784367 @default.
• W4253844036 hasRelatedWork W3123420543 @default.
• W4253844036 hasRelatedWork W4246222824 @default.
• W4253844036 hasVolume "14" @default.
• W4253844036 isParatext "false" @default.
• W4253844036 isRetracted "false" @default.
• W4253844036 workType "article" @default.