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- W4253921695 abstract "Dicentric chromosomes are genetically unstable and depress the rate of cell division in Saccharomyces cerevisiae. We have characterized the effects of a conditionally dicentric chromosome on the cell division cycle by using microscopy, flow cytometry, and an assay for histone H1 kinase activity. Activating the dicentric chromosome induced a delay in the cell cycle after DNA replication and before anaphase. The delay occurred in the absence of RAD9, a gene required to arrest cell division in response to DNA damage. The rate of dicentric chromosome loss, however, was elevated in the rad9 mutant. A mutation in BUB2, a gene required for arrest of cell division in response to loss of microtubule function, diminished the delay. Both RAD9 and BUB2 appear to be involved in the cellular response to a dicentric chromosome, since the conditionally dicentric rad9 bub2 double mutant was highly inviable. We conclude that a dicentric chromosome results in chromosome breakage and spindle aberrations prior to nuclear division that normally activate mitotic checkpoints, thereby delaying the onset of anaphase." @default.
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- W4253921695 date "1992-09-01" @default.
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- W4253921695 title "A Delay in the <i>Saccharomyces cerevisiae</i> Cell Cycle That Is Induced by a Dicentric Chromosome and Dependent upon Mitotic Checkpoints" @default.
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- W4253921695 doi "https://doi.org/10.1128/mcb.12.9.3857-3864.1992" @default.
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