FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4253953536> ?p ?o ?g. }

• W4253953536 endingPage "1858" @default.
• W4253953536 startingPage "1857" @default.
• W4253953536 abstract "Authors' reply Sir—Bruce Trathen and Sue Byers point out that the absence of 6-acetylmorphine could not exclude the use of heroin by the baker. 6-acetylmorphine is not always detected in the urine of heroin users, although it is found in more than 60% of cases with an assay of sufficient sensitivity. We excluded heroin use because of the absence of the heroin metabolite in three specimens, the history provided by the baker, and the results of the analysis of the tea. They also note that a blood concentration of morphine of 3 mg/L could indicate habitual heroin use. This concentration may be achieved initially with a high dose of intravenous heroin, but is unlikely to be sustained given the short half-life of morphine. Such concentrations are not seen even in heroin-related deaths of habitual users tolerant to the drug. Their comment that 3 mg/L morphine is surprisingly high for a supposed oral intake of 280 mg morphine, ignores the fact that non-linear absorption and kinetics will apply in high doses and lead to a non-linear increase in blood concentrations with dose, and that there is a wide individual variation in plasma concentrations after administration of standard doses.1Selavka CM Poppy seed ingestion as a contributing factor to opiate-positive urinalysis results: the Pacific perspective.J Forensic Sci. 1991; 36: 685-696PubMed Google Scholar Rainer Nowack is presumably not aware of the published research that shows substantial concentrations of morphine can be found in poppy seed, or that ingestion of poppy seed in cakes and buns can lead to a false conclusion of heroin use.2Pelders MG Ros JJW Poppy seeds: differences in morphine and codeine content and variation in inter- and intra-individual excretion.J Forensic Sci. 1996; 41: 209-212PubMed Google Scholar, 3Lo DST Chua TH Poppy seeds: implications of consumption.Med Sci Law. 1992; 32: 296-302PubMed Google Scholar We stand by our original letter and are now aware of a further two cases of morphine addiction from poppy tea. Drug use was not suspected at first and urine was not screened. The patient did not use cocaine, amphetamines, alcohol, or benzodiazepines; over several years, all urine screens were negative. One-off use of another convulsant drug is unlikely. Poppy tea and the baker's first seizureIn their report on the consumption of poppy-seed tea by a baker, Mark King and co-workers (Sept 6, p 716)1 make an error in their interpretation of the data when they state “the use of heroin was excluded by the absence of its distinguishing metabolite, 6-acetylmorphine”. The non-detection of 6-acetylmorphine does not exclude the use of heroin. Full-Text PDF Poppy tea and the baker' first seizureMark King and colleagues'1 report on poppy seed as a source of morphine intoxication contrasts with current knowledge on the opioid content of ripe poppy seed. Full-Text PDF Poppy tea and the baker' first seizureThe relation between the patient's poppy habit and his seizure is not established based on the available data in Mark King and colleagues' report1. Although experimental models in which morphine is microinjected into various brain regions of animals show a proconvulsant effect,2 convulsant effects of opiates are not consistently seen in human beings. When noted, they are generally related to hypoxia or cerebral oedema, which are themselves due to respiratory depression or pulmonary oedema.3 Indeed, clinical experience reflects this since seizures are rare even after large intravenous overdose. Full-Text PDF" @default.
• W4253953536 created "2022-05-12" @default.
• W4253953536 creator A5028338227 @default.
• W4253953536 creator A5033823158 @default.
• W4253953536 creator A5054067653 @default.
• W4253953536 creator A5082597499 @default.
• W4253953536 date "1997-12-01" @default.
• W4253953536 modified "2023-09-26" @default.
• W4253953536 title "Poppy tea and the baker' first seizure" @default.
• W4253953536 doi "https://doi.org/10.1016/s0140-6736(05)63687-2" @default.
• W4253953536 hasPublicationYear "1997" @default.
• W4253953536 type Work @default.
• W4253953536 citedByCount "0" @default.
• W4253953536 crossrefType "journal-article" @default.
• W4253953536 hasAuthorship W4253953536A5028338227 @default.
• W4253953536 hasAuthorship W4253953536A5033823158 @default.
• W4253953536 hasAuthorship W4253953536A5054067653 @default.
• W4253953536 hasAuthorship W4253953536A5082597499 @default.
• W4253953536 hasBestOaLocation W42539535361 @default.
• W4253953536 hasConcept C126322002 @default.
• W4253953536 hasConcept C158342456 @default.
• W4253953536 hasConcept C170493617 @default.
• W4253953536 hasConcept C185592680 @default.
• W4253953536 hasConcept C193230392 @default.
• W4253953536 hasConcept C2776295790 @default.
• W4253953536 hasConcept C2777389121 @default.
• W4253953536 hasConcept C2777866328 @default.
• W4253953536 hasConcept C2778140631 @default.
• W4253953536 hasConcept C2778903686 @default.
• W4253953536 hasConcept C2779225474 @default.
• W4253953536 hasConcept C2780026642 @default.
• W4253953536 hasConcept C2780035454 @default.
• W4253953536 hasConcept C42407357 @default.
• W4253953536 hasConcept C43617362 @default.
• W4253953536 hasConcept C59822182 @default.
• W4253953536 hasConcept C71924100 @default.
• W4253953536 hasConcept C86803240 @default.
• W4253953536 hasConcept C98274493 @default.
• W4253953536 hasConceptScore W4253953536C126322002 @default.
• W4253953536 hasConceptScore W4253953536C158342456 @default.
• W4253953536 hasConceptScore W4253953536C170493617 @default.
• W4253953536 hasConceptScore W4253953536C185592680 @default.
• W4253953536 hasConceptScore W4253953536C193230392 @default.
• W4253953536 hasConceptScore W4253953536C2776295790 @default.
• W4253953536 hasConceptScore W4253953536C2777389121 @default.
• W4253953536 hasConceptScore W4253953536C2777866328 @default.
• W4253953536 hasConceptScore W4253953536C2778140631 @default.
• W4253953536 hasConceptScore W4253953536C2778903686 @default.
• W4253953536 hasConceptScore W4253953536C2779225474 @default.
• W4253953536 hasConceptScore W4253953536C2780026642 @default.
• W4253953536 hasConceptScore W4253953536C2780035454 @default.
• W4253953536 hasConceptScore W4253953536C42407357 @default.
• W4253953536 hasConceptScore W4253953536C43617362 @default.
• W4253953536 hasConceptScore W4253953536C59822182 @default.
• W4253953536 hasConceptScore W4253953536C71924100 @default.
• W4253953536 hasConceptScore W4253953536C86803240 @default.
• W4253953536 hasConceptScore W4253953536C98274493 @default.
• W4253953536 hasIssue "9094" @default.
• W4253953536 hasLocation W42539535361 @default.
• W4253953536 hasOpenAccess W4253953536 @default.
• W4253953536 hasPrimaryLocation W42539535361 @default.
• W4253953536 hasRelatedWork W1189795309 @default.
• W4253953536 hasRelatedWork W1570030466 @default.
• W4253953536 hasRelatedWork W1929825044 @default.
• W4253953536 hasRelatedWork W2006804590 @default.
• W4253953536 hasRelatedWork W2082647614 @default.
• W4253953536 hasRelatedWork W2137408971 @default.
• W4253953536 hasRelatedWork W2154488041 @default.
• W4253953536 hasRelatedWork W2325361060 @default.
• W4253953536 hasRelatedWork W2474611957 @default.
• W4253953536 hasRelatedWork W2917829055 @default.
• W4253953536 hasVolume "350" @default.
• W4253953536 isParatext "false" @default.
• W4253953536 isRetracted "false" @default.
• W4253953536 workType "article" @default.