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- W4253990192 abstract "The pre-TCR complex regulates the transition from CD4–CD8– double-negative (DN) to CD4+CD8+ double-positive (DP) thymocytes during T cell development. In CD45– / – mice there is an accumulation of DN cells, suggesting a possible role for CD45 in pre-TCR signaling. We therefore crossed CD45– / – with Rag-1– / – mice to investigate the signaling functions of the CD3 complex in DN thymocytes. Remarkably, treatment of Rag-1– / – / CD45– / – mice with a CD3 mAb caused maturation to the DP stage at only 3 % of the level measured in Rag-1– / – mice. Furthermore, ligation of the CD3 complex on Rag-1– / – / CD45– / – thymocytes in vitro induced less tyrosine phosphorylation in specific proteins when compared to Rag-1– / – thymocytes. CD45– / – mice were also crossed with pLGFA mice expressing a constitutively active form of the lck tyrosine kinase which restored the DN to DP transition to near normal levels. Our results are consistent with a model in which CD45-activated p56lck is critical for pre-TCR signal transduction." @default.
- W4253990192 created "2022-05-12" @default.
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- W4253990192 date "1999-08-01" @default.
- W4253990192 modified "2023-09-25" @default.
- W4253990192 title "The CD45 tyrosine phosphatase regulates CD3-induced signal transduction and T cell development in recombinase-deficient mice: restoration of pre-TCR function by active p56lck" @default.
- W4253990192 doi "https://doi.org/10.1002/(sici)1521-4141(199908)29:08<2376::aid-immu2376>3.3.co;2-z" @default.
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