Matches in SemOpenAlex for { <https://semopenalex.org/work/W4253997908> ?p ?o ?g. }
- W4253997908 endingPage "2860" @default.
- W4253997908 startingPage "2855" @default.
- W4253997908 abstract "The Escherichia coli leader peptidase has been vital for unravelling problems in membrane assembly and protein export. The role of this essential peptidase is to remove amino-terminal leader peptides from exported proteins after they have crossed the plasma membrane. Strikingly, almost ail periplasmic proteins, many outer membrane proteins, and a few inner membrane proteins are made with cleavable leader peptides that are removed by this peptidase. This enzyme of 323 amino acid residues spans the membrane twice, with its large carboxyl-terminal domain protruding into the periplasm. Recent discoveries show that its membrane orientation is controlled by positively charged residues that border (on the cytosolic side) the transmembrane segments. Cleavable pre-proteins must have small residues at –1 and a small or aliphatic residue at –3 (with respect to the cleavage site). Leader peptidase does not require a histidine or cysteine amino acid for catalysis. Interestingly, serine 90 and aspartic acid 153 are essential for catalysis and are also conserved in a mitochondrial leader peptidase, which is 30.7% homologous with the bacterial enzyme over a 101-residue stretch." @default.
- W4253997908 created "2022-05-12" @default.
- W4253997908 creator A5053610737 @default.
- W4253997908 date "1991-12-01" @default.
- W4253997908 modified "2023-10-04" @default.
- W4253997908 title "Leader peptidase" @default.
- W4253997908 cites W1479888353 @default.
- W4253997908 cites W1489106209 @default.
- W4253997908 cites W1489755499 @default.
- W4253997908 cites W1507592137 @default.
- W4253997908 cites W1518819591 @default.
- W4253997908 cites W1526405993 @default.
- W4253997908 cites W1550654653 @default.
- W4253997908 cites W1554748597 @default.
- W4253997908 cites W1562879210 @default.
- W4253997908 cites W1570569355 @default.
- W4253997908 cites W1571047021 @default.
- W4253997908 cites W1596934991 @default.
- W4253997908 cites W1611887129 @default.
- W4253997908 cites W1667874699 @default.
- W4253997908 cites W1912879893 @default.
- W4253997908 cites W1974216104 @default.
- W4253997908 cites W1983257768 @default.
- W4253997908 cites W1987735486 @default.
- W4253997908 cites W2003253308 @default.
- W4253997908 cites W2026495415 @default.
- W4253997908 cites W2042826426 @default.
- W4253997908 cites W2068955651 @default.
- W4253997908 cites W2072220895 @default.
- W4253997908 cites W2076957725 @default.
- W4253997908 cites W2089710176 @default.
- W4253997908 cites W2094922867 @default.
- W4253997908 cites W2095046337 @default.
- W4253997908 cites W2096381280 @default.
- W4253997908 cites W2132665360 @default.
- W4253997908 cites W2137277059 @default.
- W4253997908 cites W2146923243 @default.
- W4253997908 cites W2309073869 @default.
- W4253997908 cites W2436075400 @default.
- W4253997908 cites W262216995 @default.
- W4253997908 cites W29994464 @default.
- W4253997908 doi "https://doi.org/10.1111/j.1365-2958.1991.tb01844.x" @default.
- W4253997908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1809829" @default.
- W4253997908 hasPublicationYear "1991" @default.
- W4253997908 type Work @default.
- W4253997908 citedByCount "53" @default.
- W4253997908 countsByYear W42539979082014 @default.
- W4253997908 countsByYear W42539979082017 @default.
- W4253997908 countsByYear W42539979082018 @default.
- W4253997908 countsByYear W42539979082019 @default.
- W4253997908 crossrefType "journal-article" @default.
- W4253997908 hasAuthorship W4253997908A5053610737 @default.
- W4253997908 hasConcept C104317684 @default.
- W4253997908 hasConcept C118892022 @default.
- W4253997908 hasConcept C144647389 @default.
- W4253997908 hasConcept C146587185 @default.
- W4253997908 hasConcept C170493617 @default.
- W4253997908 hasConcept C181199279 @default.
- W4253997908 hasConcept C201663137 @default.
- W4253997908 hasConcept C24530287 @default.
- W4253997908 hasConcept C2776414213 @default.
- W4253997908 hasConcept C2778460671 @default.
- W4253997908 hasConcept C2779201268 @default.
- W4253997908 hasConcept C2781338088 @default.
- W4253997908 hasConcept C41625074 @default.
- W4253997908 hasConcept C515207424 @default.
- W4253997908 hasConcept C547475151 @default.
- W4253997908 hasConcept C55493867 @default.
- W4253997908 hasConcept C65871279 @default.
- W4253997908 hasConcept C86803240 @default.
- W4253997908 hasConceptScore W4253997908C104317684 @default.
- W4253997908 hasConceptScore W4253997908C118892022 @default.
- W4253997908 hasConceptScore W4253997908C144647389 @default.
- W4253997908 hasConceptScore W4253997908C146587185 @default.
- W4253997908 hasConceptScore W4253997908C170493617 @default.
- W4253997908 hasConceptScore W4253997908C181199279 @default.
- W4253997908 hasConceptScore W4253997908C201663137 @default.
- W4253997908 hasConceptScore W4253997908C24530287 @default.
- W4253997908 hasConceptScore W4253997908C2776414213 @default.
- W4253997908 hasConceptScore W4253997908C2778460671 @default.
- W4253997908 hasConceptScore W4253997908C2779201268 @default.
- W4253997908 hasConceptScore W4253997908C2781338088 @default.
- W4253997908 hasConceptScore W4253997908C41625074 @default.
- W4253997908 hasConceptScore W4253997908C515207424 @default.
- W4253997908 hasConceptScore W4253997908C547475151 @default.
- W4253997908 hasConceptScore W4253997908C55493867 @default.
- W4253997908 hasConceptScore W4253997908C65871279 @default.
- W4253997908 hasConceptScore W4253997908C86803240 @default.
- W4253997908 hasIssue "12" @default.
- W4253997908 hasLocation W42539979081 @default.
- W4253997908 hasLocation W42539979082 @default.
- W4253997908 hasOpenAccess W4253997908 @default.
- W4253997908 hasPrimaryLocation W42539979081 @default.
- W4253997908 hasRelatedWork W1986665696 @default.
- W4253997908 hasRelatedWork W2014405748 @default.
- W4253997908 hasRelatedWork W2021345678 @default.
- W4253997908 hasRelatedWork W2022304291 @default.
- W4253997908 hasRelatedWork W2029131358 @default.