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- W4254046823 abstract "OBJECTIVES: The salicylate mesalazine is commonly used for the treatment of inflammatory bowel diseases, yet its precise mechanism of action is unknown. Because transcription factor NF-κB plays an important role in inflammatory bowel diseases, we investigated the effects of mesalazine therapy on NF-κB activation in patients with ulcerative colitis. METHODS: A total of 20 patients with moderately active ulcerative colitis received mesalazine for 8 wk. Biopsies were taken before and after drug administration and analyzed for NF-κB activation using an antibody specific for active NF-κB. RESULTS: In biopsies of active ulcerative colitis but not in noninflamed mucosa, activation of NF-κB was detected predominantly in macrophages. Mesalazine therapy resulted in a strong abrogation of NF-κB activation in situ . CONCLUSIONS: Our results suggest that the therapeutic properties of mesalazine rely at least in part on the inhibition of NF-κB activation, resulting in the suppression of proinflammatory gene expression in the inflamed mucosa." @default.
- W4254046823 created "2022-05-12" @default.
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- W4254046823 date "2000-12-01" @default.
- W4254046823 modified "2023-09-30" @default.
- W4254046823 title "Mesalazine inhibits activation of transcription factor NF-κB in inflamed mucosa of patients with ulcerative colitis" @default.
- W4254046823 doi "https://doi.org/10.1016/s0002-9270(00)02153-5" @default.
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