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- W4254060370 abstract "Interleukin-1 (IL-1) is an important immunoregulatory peptide produced by monocytes and macrophages. Because mononuclear phagocytes are morphologically and functionally heterogeneous, we examined whether they differ in their ability to elaborate IL-1. We used discontinuous Percoll gradients to obtain five density-defined human blood monocyte subpopulations. Unfractionated monocytes and their subsets were compared for their ability to stimulate thymocyte proliferation. Supernatants obtained from the denser monocytes consistently contained more IL-1 activity than did supernatants from the less dense cells. This difference in IL-1 activity was the result of differences in IL-1 elaboration, not the selective production of an inhibitor of IL-1- induced thymocyte proliferation. These data demonstrate that density- defined human monocyte subpopulations differ in their capacity to elaborate IL-1." @default.
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- W4254060370 date "1985-08-01" @default.
- W4254060370 modified "2023-09-29" @default.
- W4254060370 title "Differential interleukin-1 elaboration by density-defined human monocyte subpopulations" @default.
- W4254060370 doi "https://doi.org/10.1182/blood.v66.2.298.bloodjournal662298" @default.
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