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- W4254092443 abstract "The development and promulgation of drinking water regulations to protect exposed human populations from contaminants that may occur in public drinking water supplies has been a major regulatory concern and effort of the United States Environmental Protection Agency for decades. Risk assessment, as applied in the development of drinking water regulations, involves the quantification of the level below which adverse health effects are not expected to occur. Traditionally, the oral reference dose (RfD) has been the preferred approach for characterizing these noncancer health risks. The benchmark dose approach to derive RfDs has increasingly gained scientific and regulatory acceptance as a risk assessment methodology since its introduction in 1984. Similarly, the use of categorical regression techniques were introduced at about the same time. The objective of this paper is to present an evaluation of the strengths and weaknesses of each risk assessment method as related to the development of drinking water criteria for noncarcinogenic chemicals. The data base requirements, performance record, mathematical or statistical basis, and other parameters are described and compared." @default.
- W4254092443 created "2022-05-12" @default.
- W4254092443 date "1998-06-01" @default.
- W4254092443 modified "2023-09-25" @default.
- W4254092443 title "The American Health Foundation's 6th International Course on the Safety Assessment of Medicines" @default.
- W4254092443 doi "https://doi.org/10.1006/rtph.1998.1236" @default.
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