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- W4254094586 abstract "The v-myb oncogene causes acute myelomonocytic leukemia in chickens and transforms avian myeloid cells in vitro. Its product, p48v-myb, is a short-lived nuclear protein which binds DNA. We demonstrate that p48v-myb can function as a trans activator of gene expression in transient DNA transfection assays. trans activation requires the highly conserved amino-terminal DNA-binding domain and the less highly conserved carboxyl-terminal domain of p48v-myb, both of which are required for transformation. Multiple copies of a consensus sequence for DNA binding by p48v-myb inserted upstream of a herpes simplex virus thymidine kinase promoter are strongly stimulatory for transcriptional activation by a v-myb-VP16 fusion protein but not by p48v-myb itself, suggesting that the binding of p48v-myb to DNA may not be sufficient for trans activation." @default.
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- W4254094586 date "1990-05-01" @default.
- W4254094586 modified "2023-09-29" @default.
- W4254094586 title "trans activation of gene expression by v-myb" @default.
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- W4254094586 doi "https://doi.org/10.1128/mcb.10.5.2285-2293.1990" @default.
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