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- W4254111399 abstract "Im Doppel: Die Dimerisierung monomerer Peptidliganden für die PDZ-Domänen des Proteins PSD-95 (postsynaptische Dichte 95) liefert leistungsfähige Inhibitoren von Protein-Protein-Wechselwirkungen, die in Blutplasma stabil sind. Durch Optimierung der Länge des Polyethylenglycol-Linkers gelangt man zu Inhibitoren der PDZ1-2-Domäne (siehe Bild) mit bislang unerreichter Affinität. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
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- W4254111399 date "2009-11-24" @default.
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- W4254111399 title "Design and Synthesis of Highly Potent and Plasma-Stable Dimeric Inhibitors of the PSD-95-NMDA Receptor Interaction" @default.
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