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• W4254140433 abstract "To evaluate the serum levels of leptin and adiponectin in patients with systemic lupus erythematosus (SLE) and correlate their levels with disease activity, presence of autoantibodies and clinical manifestations. 52 women with SLE and 33 healthy women were evaluated. The patients were divided into two groups, the first with active SLE and the second with inactive SLE. Patients with SLEDAI ≥3 were considered active. Serum levels of leptin (ng/mL) and adiponectin (μg/mL) were measured by enzyme immunoassay. There was a significant difference in leptin levels between SLE and controls (20.7 ± 17.1 vs. 8.0 ± 5.0 ng/mL, p < 0.001), but no significant difference in adiponectin levels (87 5 ± 69.7 vs. 118.1 ± 70.6 pg/mL, p = 0.053). No significant difference in levels of leptin and adiponectin was noted between inactive and active SLE groups. There was a significant association between low levels of leptin and positivity for anticardiolipin (aCL) (p = 0.025) and lupus anticoagulant (LA) (p = 0.003) and a significant association between high levels of leptin and the presence of renal disease (p < 0.001). However, there was no association between adiponectin levels with autoantibodies and clinical features in SLE patients. Patients with SLE had elevated leptin levels, with association with renal involvement. Leptin and adiponectin were not correlated with disease activity. Low levels of leptin have been associated with the presence of LA and aCL. Avaliar os níveis séricos de leptina e adiponectina em pacientes com lúpus eritematoso sistêmico (LES) e correlacionar seus níveis com atividade inflamatória, presença de autoanticorpos e manifestações clínicas. Foram avaliadas 52 mulheres com LES e 33 mulheres saudáveis. As pacientes foram divididas em dois grupos, o primeiro com LES ativo e o segundo com LES inativo. Foram consideradas em atividade as paciente com Sledai ≥ 3. Os níveis séricos de leptina (ng/mL) e adiponectina (ug/mL) foram medidos por ensaio imunoenzimático. Houve diferença significativa nos níveis de leptina entre LES e controle (20,7 ± 17,1 vs. 8,0 ± 5,0 ng/mL, p < 0,001), mas não houve diferença significativa nos níveis de adiponectina (87,5 ± 69,7 vs. 118,1 ± 70,6 ug/mL, p = 0,053). Entre LES inativo e ativo, não houve diferença significativa dos níveis de leptina e adiponectina. Houve uma associação significativa entre os baixos níveis de leptina e positividade para anticardiolipina (aCL) (p = 0,025) e anticoagulante lúpico (LA) (p = 0,003) e uma associação significativa entre níveis elevados de leptina e da presença de manifestação renal (p < 0,001). No entanto, não houve associação entre adiponectina com autoanticorpos e características clínicas nas pacientes. Pacientes com LES apresentaram nível elevado de leptina, com associação ao envolvimento renal. A leptina e a adiponectina não se correlacionaram com a atividade da doença. Baixos níveis de leptina foram associados com a presença de LA e aCL." @default.
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• W4254140433 date "2015-03-01" @default.
• W4254140433 modified "2023-10-14" @default.
• W4254140433 title "Leptin and adiponectin in patients with systemic lupus erythematosus: clinical and laboratory correlations" @default.
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• W4254140433 doi "https://doi.org/10.1016/j.rbre.2014.08.013" @default.
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