FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4254146802> ?p ?o ?g. }

• W4254146802 endingPage "1503" @default.
• W4254146802 startingPage "1493" @default.
• W4254146802 abstract "The apolipoprotein apoC-III plays an important role in plasma triglyceride metabolism. It is predominantly produced in liver, and its hepatic expression is inhibited by insulin. To elucidate the inhibitory mechanism of insulin in apoC-III expression, we delivered forkhead box O1 (Foxo1) cDNA to hepatocytes by adenovirus-mediated gene transfer. Foxo1 stimulated hepatic apoC-III expression and correlated with the ability of Foxo1 to bind to its consensus site in the apoC-III promoter. Deletion or mutation of the Foxo1 binding site abolished insulin response and Foxo1-mediated stimulation. Likewise, Foxo1 also mediated insulin action on intestinal apoC-III expression in enterocytes. Furthermore, elevated Foxo1 production in liver augmented hepatic apoC-III expression, resulting in increased plasma triglyceride levels and impaired fat tolerance in mice. Transgenic mice expressing a constitutively active Foxo1 allele exhibited hypertriglyceridemia. Moreover, we show that hepatic Foxo1 expression becomes deregulated as a result of insulin deficiency or insulin resistance, culminating in significantly elevated Foxo1 production, along with its skewed nuclear distribution, in livers of diabetic NOD or db/db mice. While loss of insulin response is associated with unrestrained apoC-III production and impaired triglyceride metabolism, these data suggest that Foxo1 provides a molecular link between insulin deficiency or resistance and aberrant apoC-III production in the pathogenesis of diabetic hypertriglyceridemia." @default.
• W4254146802 created "2022-05-12" @default.
• W4254146802 creator A5003290165 @default.
• W4254146802 creator A5007779347 @default.
• W4254146802 creator A5014061259 @default.
• W4254146802 creator A5037116075 @default.
• W4254146802 creator A5062034229 @default.
• W4254146802 creator A5076213855 @default.
• W4254146802 creator A5090431000 @default.
• W4254146802 date "2004-11-15" @default.
• W4254146802 modified "2023-10-17" @default.
• W4254146802 title "Foxo1 mediates insulin action on apoC-III and triglyceride metabolism" @default.
• W4254146802 cites W1495673540 @default.
• W4254146802 cites W1521754963 @default.
• W4254146802 cites W1527680278 @default.
• W4254146802 cites W1889257304 @default.
• W4254146802 cites W1963872182 @default.
• W4254146802 cites W1965947775 @default.
• W4254146802 cites W1972418826 @default.
• W4254146802 cites W1979147887 @default.
• W4254146802 cites W1984977911 @default.
• W4254146802 cites W2024529788 @default.
• W4254146802 cites W2026559965 @default.
• W4254146802 cites W2026674552 @default.
• W4254146802 cites W2036837630 @default.
• W4254146802 cites W2047589448 @default.
• W4254146802 cites W2059911808 @default.
• W4254146802 cites W2062390485 @default.
• W4254146802 cites W2076103389 @default.
• W4254146802 cites W2081359005 @default.
• W4254146802 cites W2090759987 @default.
• W4254146802 cites W2091016673 @default.
• W4254146802 cites W2107664641 @default.
• W4254146802 cites W2112858955 @default.
• W4254146802 cites W2127958304 @default.
• W4254146802 cites W2146685672 @default.
• W4254146802 cites W2164468903 @default.
• W4254146802 cites W2184335570 @default.
• W4254146802 cites W2185554201 @default.
• W4254146802 cites W2334791394 @default.
• W4254146802 cites W2348229247 @default.
• W4254146802 cites W2403507619 @default.
• W4254146802 cites W4234908756 @default.
• W4254146802 cites W4240809199 @default.
• W4254146802 cites W4246132906 @default.
• W4254146802 doi "https://doi.org/10.1172/jci200419992" @default.
• W4254146802 hasPublicationYear "2004" @default.
• W4254146802 type Work @default.
• W4254146802 citedByCount "223" @default.
• W4254146802 countsByYear W42541468022012 @default.
• W4254146802 countsByYear W42541468022013 @default.
• W4254146802 countsByYear W42541468022014 @default.
• W4254146802 countsByYear W42541468022015 @default.
• W4254146802 countsByYear W42541468022016 @default.
• W4254146802 countsByYear W42541468022017 @default.
• W4254146802 countsByYear W42541468022018 @default.
• W4254146802 countsByYear W42541468022019 @default.
• W4254146802 countsByYear W42541468022020 @default.
• W4254146802 countsByYear W42541468022021 @default.
• W4254146802 countsByYear W42541468022022 @default.
• W4254146802 countsByYear W42541468022023 @default.
• W4254146802 crossrefType "journal-article" @default.
• W4254146802 hasAuthorship W4254146802A5003290165 @default.
• W4254146802 hasAuthorship W4254146802A5007779347 @default.
• W4254146802 hasAuthorship W4254146802A5014061259 @default.
• W4254146802 hasAuthorship W4254146802A5037116075 @default.
• W4254146802 hasAuthorship W4254146802A5062034229 @default.
• W4254146802 hasAuthorship W4254146802A5076213855 @default.
• W4254146802 hasAuthorship W4254146802A5090431000 @default.
• W4254146802 hasBestOaLocation W42541468021 @default.
• W4254146802 hasConcept C112446052 @default.
• W4254146802 hasConcept C126322002 @default.
• W4254146802 hasConcept C13028836 @default.
• W4254146802 hasConcept C134018914 @default.
• W4254146802 hasConcept C140149449 @default.
• W4254146802 hasConcept C2776919658 @default.
• W4254146802 hasConcept C2777391703 @default.
• W4254146802 hasConcept C2778163477 @default.
• W4254146802 hasConcept C2778913445 @default.
• W4254146802 hasConcept C2779306644 @default.
• W4254146802 hasConcept C2780072125 @default.
• W4254146802 hasConcept C55493867 @default.
• W4254146802 hasConcept C62478195 @default.
• W4254146802 hasConcept C71924100 @default.
• W4254146802 hasConcept C75217442 @default.
• W4254146802 hasConcept C8243546 @default.
• W4254146802 hasConcept C86803240 @default.
• W4254146802 hasConceptScore W4254146802C112446052 @default.
• W4254146802 hasConceptScore W4254146802C126322002 @default.
• W4254146802 hasConceptScore W4254146802C13028836 @default.
• W4254146802 hasConceptScore W4254146802C134018914 @default.
• W4254146802 hasConceptScore W4254146802C140149449 @default.
• W4254146802 hasConceptScore W4254146802C2776919658 @default.
• W4254146802 hasConceptScore W4254146802C2777391703 @default.
• W4254146802 hasConceptScore W4254146802C2778163477 @default.
• W4254146802 hasConceptScore W4254146802C2778913445 @default.
• W4254146802 hasConceptScore W4254146802C2779306644 @default.
• W4254146802 hasConceptScore W4254146802C2780072125 @default.

• next