Matches in SemOpenAlex for { <https://semopenalex.org/work/W4254152058> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4254152058 abstract "Abstract Background Treponema pallidum ( T. pallidum ) infection evokes significant immune responses, resulting in tissue damage. The immune mechanism underlying T. pallidum infection is still unclear, although microRNAs (miRNAs) have been shown to influence immune cell function and, consequently, the generation of antibody responses during other microbe infections. However, these mechanisms are unknown for T. pallidum . Methods In this study, we performed a comprehensive analysis of differentially expressed miRNAs in healthy individuals, untreated patients with syphilis, patients in the serofast state, and serologically cured patients. miRNAs were profiled from the peripheral blood of patients obtained at the time of serological diagnosis. Then, both the target sequence analysis of these different miRNAs and pathway analysis were performed to identify important immune and cell signaling pathways. Quantitative reverse transcription-polymerase chain reaction (RT-PCR) was performed for microRNA analysis. Results A total of 89 differentially regulated miRNAs were identified. Following RT-qPCR confirmation, three miRNAs (hsa-miR-195-5p, hsa-miR-223-3p, hsa-miR-589-3p) showed significant differences in the serofast and serologically cured states ( P <0.05). One miRNA (hsa-miR-195-5p) showed significant differences between untreated patients and healthy individuals. Conclusions This is the first study of miRNA expression differences in peripheral blood mononuclear cells (PBMCs) in different stages of T. pallium infection. Our study suggests that the combination of three miRNAs has great potential to serve as a non-invasive biomarker of T. pallium infections, which will facilitate better diagnosis and treatment of T. pallium infections." @default.
- W4254152058 created "2022-05-12" @default.
- W4254152058 creator A5005179685 @default.
- W4254152058 creator A5005994188 @default.
- W4254152058 creator A5006022879 @default.
- W4254152058 creator A5006111318 @default.
- W4254152058 creator A5017628883 @default.
- W4254152058 creator A5021564027 @default.
- W4254152058 creator A5040414089 @default.
- W4254152058 creator A5042302046 @default.
- W4254152058 creator A5052922134 @default.
- W4254152058 creator A5065035491 @default.
- W4254152058 creator A5069786342 @default.
- W4254152058 creator A5071672663 @default.
- W4254152058 creator A5078452121 @default.
- W4254152058 creator A5091446112 @default.
- W4254152058 date "2020-01-27" @default.
- W4254152058 modified "2023-09-27" @default.
- W4254152058 title "MicroRNA expression profiling of peripheral blood mononuclear cells associated with syphilis" @default.
- W4254152058 cites W1755308529 @default.
- W4254152058 cites W2006426795 @default.
- W4254152058 cites W2111533516 @default.
- W4254152058 cites W2160124608 @default.
- W4254152058 cites W2811481829 @default.
- W4254152058 doi "https://doi.org/10.21203/rs.2.9964/v5" @default.
- W4254152058 hasPublicationYear "2020" @default.
- W4254152058 type Work @default.
- W4254152058 citedByCount "0" @default.
- W4254152058 crossrefType "posted-content" @default.
- W4254152058 hasAuthorship W4254152058A5005179685 @default.
- W4254152058 hasAuthorship W4254152058A5005994188 @default.
- W4254152058 hasAuthorship W4254152058A5006022879 @default.
- W4254152058 hasAuthorship W4254152058A5006111318 @default.
- W4254152058 hasAuthorship W4254152058A5017628883 @default.
- W4254152058 hasAuthorship W4254152058A5021564027 @default.
- W4254152058 hasAuthorship W4254152058A5040414089 @default.
- W4254152058 hasAuthorship W4254152058A5042302046 @default.
- W4254152058 hasAuthorship W4254152058A5052922134 @default.
- W4254152058 hasAuthorship W4254152058A5065035491 @default.
- W4254152058 hasAuthorship W4254152058A5069786342 @default.
- W4254152058 hasAuthorship W4254152058A5071672663 @default.
- W4254152058 hasAuthorship W4254152058A5078452121 @default.
- W4254152058 hasAuthorship W4254152058A5091446112 @default.
- W4254152058 hasBestOaLocation W42541520581 @default.
- W4254152058 hasConcept C104317684 @default.
- W4254152058 hasConcept C137061746 @default.
- W4254152058 hasConcept C145059251 @default.
- W4254152058 hasConcept C159047783 @default.
- W4254152058 hasConcept C159654299 @default.
- W4254152058 hasConcept C202751555 @default.
- W4254152058 hasConcept C203014093 @default.
- W4254152058 hasConcept C2776983459 @default.
- W4254152058 hasConcept C2780187896 @default.
- W4254152058 hasConcept C2781197716 @default.
- W4254152058 hasConcept C3013748606 @default.
- W4254152058 hasConcept C45189115 @default.
- W4254152058 hasConcept C48023723 @default.
- W4254152058 hasConcept C54355233 @default.
- W4254152058 hasConcept C86803240 @default.
- W4254152058 hasConcept C8891405 @default.
- W4254152058 hasConceptScore W4254152058C104317684 @default.
- W4254152058 hasConceptScore W4254152058C137061746 @default.
- W4254152058 hasConceptScore W4254152058C145059251 @default.
- W4254152058 hasConceptScore W4254152058C159047783 @default.
- W4254152058 hasConceptScore W4254152058C159654299 @default.
- W4254152058 hasConceptScore W4254152058C202751555 @default.
- W4254152058 hasConceptScore W4254152058C203014093 @default.
- W4254152058 hasConceptScore W4254152058C2776983459 @default.
- W4254152058 hasConceptScore W4254152058C2780187896 @default.
- W4254152058 hasConceptScore W4254152058C2781197716 @default.
- W4254152058 hasConceptScore W4254152058C3013748606 @default.
- W4254152058 hasConceptScore W4254152058C45189115 @default.
- W4254152058 hasConceptScore W4254152058C48023723 @default.
- W4254152058 hasConceptScore W4254152058C54355233 @default.
- W4254152058 hasConceptScore W4254152058C86803240 @default.
- W4254152058 hasConceptScore W4254152058C8891405 @default.
- W4254152058 hasLocation W42541520581 @default.
- W4254152058 hasLocation W42541520582 @default.
- W4254152058 hasLocation W42541520583 @default.
- W4254152058 hasOpenAccess W4254152058 @default.
- W4254152058 hasPrimaryLocation W42541520581 @default.
- W4254152058 hasRelatedWork W1877066705 @default.
- W4254152058 hasRelatedWork W2017250641 @default.
- W4254152058 hasRelatedWork W2145400850 @default.
- W4254152058 hasRelatedWork W2161395634 @default.
- W4254152058 hasRelatedWork W2359789974 @default.
- W4254152058 hasRelatedWork W2389664576 @default.
- W4254152058 hasRelatedWork W2411378979 @default.
- W4254152058 hasRelatedWork W2564789827 @default.
- W4254152058 hasRelatedWork W3014834998 @default.
- W4254152058 hasRelatedWork W3030852988 @default.
- W4254152058 isParatext "false" @default.
- W4254152058 isRetracted "false" @default.
- W4254152058 workType "article" @default.