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- W4254172215 abstract "This investigation used the postantibiotic effect (PAE) and killing curves to examine the antimicrobial activity of subinhibitory (1/8 ×, 1/4 × and 1/2 × MIC) and inhibitory (1 × MIC) concentrations of ciprofloxacin against mucoid (M) and non-mucoid (NM) urinary isolates of <i>Pseudomonas aeruginosa. </i>Subinhibitory concentrations (1/8 ×, 1/4 × and 1/2 × MIC) of ciprofloxacin produced PAEs with no difference between M and NM strains. For NM strains, those with low MICs (≤1.0 mg/l) to ciprofloxacin produced significantly longer PAEs than isolates with high MICs ( > 1 mg/l). Killing curve studies demonstrated that subinhibitory concentrations of ciprofloxacin produce little effect (1/8 × MIC) or stasis (1/4 × and 1/2 × MIC) of growth for several hours. Only 1 × MIC was bactericidal for several strains. At 1/2 × and 1 × MIC, bacterial inhibition was greater against NM versus M isolates. The M phenotype of <i>P. aeruginosa </i>reduces killling by ciprofloxacin but not the PAE." @default.
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- W4254172215 date "1992-01-01" @default.
- W4254172215 modified "2023-09-28" @default.
- W4254172215 title "Antimicrobial Activity of Subinhibitory Concentrations of Ciprofloxacin against <i>Pseudomonas aeruginosa </i>as Determined by the Killing Curve Method and the Postantibiotic Effect" @default.
- W4254172215 doi "https://doi.org/10.1159/000239032" @default.
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