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- W4254172430 abstract "Oxidized LDL induces changes in several facets of the immune system, although the relationships between these facets and their contributions to atherogenesis have yet to be fully elucidated. A report in this issue of the JCI provides a novel demonstration of the adaptive immune system influencing the production of natural antibodies. The results demonstrate that injection of malondialdehyde-modified LDL promotes a Th2 response that in turn increases the titers of the natural antibody T15/EO6, which recognizes the oxidized phospholipid POVPC. Atherosclerotic lesion size in LDL receptor–deficient mice is reduced as a consequence of the increase in natural antibody titers, and IL-5 is identified as the link between the adaptive and natural immune systems." @default.
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- W4254172430 date "2004-08-01" @default.
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- W4254172430 title "IL-5 links adaptive and natural immunity in reducing atherosclerotic disease" @default.
- W4254172430 doi "https://doi.org/10.1172/jci200422561" @default.
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