Matches in SemOpenAlex for { <https://semopenalex.org/work/W4254180630> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4254180630 endingPage "5064" @default.
- W4254180630 startingPage "5064" @default.
- W4254180630 abstract "5064 Background: Prognosis of advanced endometrial cancer patients (stage IIIc and IV) is poor. In order to clarify the histopathologic prognostic factors of node-positive endometrial cancer, we performed the following analysis. Methods: A retrospective review of 55 node-positive endometrial cancer patients (44 in stage IIIc and 11 in stage IV) among 303 patients treated between 1982 and 2002 at Hokkaido University Hospital was performed. All Patients underwent primary surgical treatment including pelvic and para-aortic lymphadenectomy followed by adjuvant chemotherapy consisting of intravenous cisplatin, doxorubicin, and cyclophoshamide. Survival analyses were performed by the Kaplan-Meier curves and the log-rank test. Independent prognostic factors were determined by multivariate Cox regression analysis. Results: Multivariate analysis revealed that FIGO (1988) stage and lymph-vascular space invasion (LVSI) of the tumor were found to be independently related to poor survival . The estimated 5-year survival rate of stage IIIc patients with or without moderate/prominent LVSI was 50.9 % and 93.3 %, respectively. The difference of survival rate was statitstically significant (p=0.0024). The estimated 5-year survival rate of stage IV patients was 20.0%. In stage IIIc patients, multivariate analysis showed that LVSI alone was found to be an independent prognostic factor for survival. Prognosis of stage IIIc patients could be stratified into three groups by the number of positive para-aortic lymph node (PAN) with an estimated 5-year survival rate of 86.4% for no positive PAN (n=23), 60.4% for 1 positive PAN (n=13), 20.0% for >=2 positive PAN (n=8). The difference of survival rate between no or one positive PAN and >=2 PAN was statistically significant (p=0.0007 for no positive PAN vs >=2 PAN, p=0.0319 for one positive PAN vs >=2 positive PAN). Conclusions: LVSI was an independent prognostic factor for stage IIIc patients and their prognosis was stratified by the number of positive PAN. Postoperative therapy and follow-up modality need to be individualized according to LVSI and the number of positive PAN for stage IIIc patients. No significant financial relationships to disclose." @default.
- W4254180630 created "2022-05-12" @default.
- W4254180630 creator A5029512804 @default.
- W4254180630 creator A5044369220 @default.
- W4254180630 creator A5046213781 @default.
- W4254180630 creator A5052934233 @default.
- W4254180630 creator A5072629851 @default.
- W4254180630 creator A5088888789 @default.
- W4254180630 date "2004-07-15" @default.
- W4254180630 modified "2023-09-27" @default.
- W4254180630 title "A multivariate analysis on histopathologic prognostic factors for predicting outcome of node-positive endometrial carcinoma" @default.
- W4254180630 doi "https://doi.org/10.1200/jco.2004.22.14_suppl.5064" @default.
- W4254180630 hasPublicationYear "2004" @default.
- W4254180630 type Work @default.
- W4254180630 citedByCount "0" @default.
- W4254180630 crossrefType "journal-article" @default.
- W4254180630 hasAuthorship W4254180630A5029512804 @default.
- W4254180630 hasAuthorship W4254180630A5044369220 @default.
- W4254180630 hasAuthorship W4254180630A5046213781 @default.
- W4254180630 hasAuthorship W4254180630A5052934233 @default.
- W4254180630 hasAuthorship W4254180630A5072629851 @default.
- W4254180630 hasAuthorship W4254180630A5088888789 @default.
- W4254180630 hasConcept C10515644 @default.
- W4254180630 hasConcept C121608353 @default.
- W4254180630 hasConcept C126322002 @default.
- W4254180630 hasConcept C143998085 @default.
- W4254180630 hasConcept C146357865 @default.
- W4254180630 hasConcept C151730666 @default.
- W4254180630 hasConcept C2776283816 @default.
- W4254180630 hasConcept C2777088508 @default.
- W4254180630 hasConcept C2777546739 @default.
- W4254180630 hasConcept C2780824555 @default.
- W4254180630 hasConcept C2780849966 @default.
- W4254180630 hasConcept C38180746 @default.
- W4254180630 hasConcept C50382708 @default.
- W4254180630 hasConcept C71924100 @default.
- W4254180630 hasConcept C86803240 @default.
- W4254180630 hasConcept C90924648 @default.
- W4254180630 hasConceptScore W4254180630C10515644 @default.
- W4254180630 hasConceptScore W4254180630C121608353 @default.
- W4254180630 hasConceptScore W4254180630C126322002 @default.
- W4254180630 hasConceptScore W4254180630C143998085 @default.
- W4254180630 hasConceptScore W4254180630C146357865 @default.
- W4254180630 hasConceptScore W4254180630C151730666 @default.
- W4254180630 hasConceptScore W4254180630C2776283816 @default.
- W4254180630 hasConceptScore W4254180630C2777088508 @default.
- W4254180630 hasConceptScore W4254180630C2777546739 @default.
- W4254180630 hasConceptScore W4254180630C2780824555 @default.
- W4254180630 hasConceptScore W4254180630C2780849966 @default.
- W4254180630 hasConceptScore W4254180630C38180746 @default.
- W4254180630 hasConceptScore W4254180630C50382708 @default.
- W4254180630 hasConceptScore W4254180630C71924100 @default.
- W4254180630 hasConceptScore W4254180630C86803240 @default.
- W4254180630 hasConceptScore W4254180630C90924648 @default.
- W4254180630 hasIssue "14_suppl" @default.
- W4254180630 hasLocation W42541806301 @default.
- W4254180630 hasOpenAccess W4254180630 @default.
- W4254180630 hasPrimaryLocation W42541806301 @default.
- W4254180630 hasRelatedWork W1758517966 @default.
- W4254180630 hasRelatedWork W1978015204 @default.
- W4254180630 hasRelatedWork W1985081679 @default.
- W4254180630 hasRelatedWork W2070796723 @default.
- W4254180630 hasRelatedWork W2276997037 @default.
- W4254180630 hasRelatedWork W2364092196 @default.
- W4254180630 hasRelatedWork W2369251192 @default.
- W4254180630 hasRelatedWork W2372105188 @default.
- W4254180630 hasRelatedWork W2373165472 @default.
- W4254180630 hasRelatedWork W2898594549 @default.
- W4254180630 hasVolume "22" @default.
- W4254180630 isParatext "false" @default.
- W4254180630 isRetracted "false" @default.
- W4254180630 workType "article" @default.