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- W4254194311 abstract "Abstract Context.—The differentiation of benign mesothelial proliferations from malignant mesotheliomas may be difficult, especially when evaluating small specimens from pleural biopsies. Objective.—To explore the potential value of 2 proliferative cell markers, Ki-67 and restrictedly expressed proliferation–associated protein 86 kDa (repp86), in distinguishing between malignant mesothelioma (MM) and benign reactive mesothelial hyperplasia (MH). Design.—Thirty-six cases of MM from 26 men and 10 women with a mean age of 62.9 years (range, 36–80 years) and 22 cases of benign reactive MH from 14 male and 8 female patients with a mean age of 51.5 years (range, 15– 88 years) were included in this study. The proliferative status of the lesions was assessed by immunohistochemistry using monoclonal antibodies to Ki-S2 (repp86) and Ki-S5 (Ki-67). The labeling indices were quantified. Results.—The mean labeling indexes for Ki-67 in MM and benign reactive MH were 24.6% (range, 1%–66%) and 6.23% (range, 0%–25%), respectively. The mean labeling indexes for repp86 in MM and benign reactive MH were 26.3% (range, 0%–50%) and 3.26% (range, 0%– 21%), respectively. The average proliferative cell count was significantly higher in MM compared with benign reactive MH (P < .001). Furthermore, both markers showed a significant correlation in their expression in MM and benign reactive MH (r = 77.5, P < .001). Sensitivities of 88% and 92% and specificities of 92% and 94% were obtained at a cutoff point of 9% for Ki-67 and repp86, respectively. Conclusions.—Used in combination, Ki-67 and repp86 appear to be useful markers in differentiating MM from benign reactive MH." @default.
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- W4254194311 date "2008-04-01" @default.
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- W4254194311 title "The Diagnostic Value of Ki-67 and repp86 in Distinguishing Between Benign and Malignant Mesothelial Proliferations" @default.
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- W4254194311 doi "https://doi.org/10.5858/2008-132-694-tdvoka" @default.
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