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- W4254199946 abstract "Abstract Purpose : Multiple myeloma (MM) is a clinically and biologically heterogeneous malignancy of plasma cell. The overall survival of MM patients varies from people to people ranged from several months to decades. It is always knotty how to predict MM prognosis. The presence of circulating plasma cells (CPCs) has been associated with a worse prognosis in patients with MM. Materials and Methods : This study retrospectively analyzed CPCs in 108 cases of newly diagnosed MM patients with 8-color flow cytometry to investigate its value for outcome prediction, and combined CPCs with R-ISS to stratify the risk of MM. Results: CPCs were detected in 58/108 patients (53.7%). The optimum cutoff predicting for overall survival was determined as 0.105% by using a ROC analysis. Compared with patients with CPCs < 0.105% (n = 66，61.1%), those with CPCs ≥0.105% (n = 42, 38.9%) showed lower blood platelet count (BPC) ( P =0.038), but higher β2-microglobulin (β2-MG), lactate dehydrogenase (LDH), ferritin (FER) , and harboring P53 deletion, high-risk cytogenetic abnormality, ( P = 0.011, 0.001, 0.002, <0.001, and 0.020, respectively). The higher R-ISS stage seems to harbor higher CPCs. CPCs≥0.105% are independently factor for adverse outcome ( P <0.001). The combination of R-ISS staging system and CPCs level was used to stratify the risk of multiple myeloma，and R-ISS III stage with CPCs ≥0.105% was ranked as a real ultra-high-risk group. Conclusion: This study suggests that high CPCs is associated with an aggressive disease and that the current R-ISS system in conjunction with CPCs may facilitate the differentiation of NDMM patients. There may also is the potential significance in modifying the definitions of high-risk disease and the practice of adopting a risk-adapted initial treatment." @default.
- W4254199946 created "2022-05-12" @default.
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- W4254199946 date "2020-09-09" @default.
- W4254199946 modified "2023-10-16" @default.
- W4254199946 title "Prognostic value of circulating plasma cells in newly diagnosed multiple myeloma" @default.
- W4254199946 doi "https://doi.org/10.21203/rs.3.rs-64091/v1" @default.
- W4254199946 hasPublicationYear "2020" @default.
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