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• W4254262023 abstract "ABSTRACT Quinolones are degraded by light with loss of their antimicrobial activity, generating active species or radicals, Evidence exists that some fluoroquinolones (lomefloxacin, fleroxacin and enoxacin) induce damage to the cellular membrane and DNA cleavage by photosensitization. In this study, the genotoxic potential of the quinolones ofloxacin, nalidixic acid and ciprofloxacin (three antimicrobials frequently used in therapy) was evaluated upon irradiation with UV light by using the comet assay on cells of the Jurkat line. The results demonstrate that there are significant differences between the control groups (positive control with 50 μM H 2 O 2 , negative controls without drug and with and without irradiation) and the groups of irradiated quinolones (ofloxacin 2.76 × 10 −5 M , nalidixic acid 2.15 × 10 −4 M and ciprofloxacin 2.01 × 10 −5 M ), indicating that, at the dose of irradiation employed (necessary to produce 50% photodegradation), the photodecomposition of the quinolones enhanced DNA damage. The unirradiated drugs also exhibited genotoxicity significantly different from that of the negative control." @default.
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• W4254262023 date "2005-07-01" @default.
• W4254262023 modified "2023-10-15" @default.
• W4254262023 title "Induced and Photoinduced DNA Damage by Quinolones: Ciprofloxacin, Ofloxacin and Nalidixic Acid Determined by Comet Assay¶" @default.
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• W4254262023 doi "https://doi.org/10.1111/j.1751-1097.2005.tb01448.x" @default.
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