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- W4254303601 abstract "In contrast to other products on the market, Xeomin® contains only the therapeutically active protein, the 150 kDa botulinum neurotoxin type A. It could be demonstrated by several physico-chemical procedures that no other clostridial proteins are present in the product. Consequently, Xeomin is the product with the highest specific potency. In clinical studies it was shown that the purified neurotoxin is equally efficacious to other botulinum toxin preparations and additional clostridial proteins do not contribute to the therapeutic effect. The neurotoxin complex is stable only at acidic pH and immediately dissociates at physiological pH after injection into the muscle to liberate the active 150 kDa neurotoxin. Therefore, the complexing proteins do not influence the diffusion behaviour because of the risk of adverse reactions caused by the spread of the neurotoxin. In contrast, the complexing proteins acting as lectins could have a negative impact on the therapeutic use. Xeomin® is stable at room temperature for a period of 4 years and does not require refrigeration, which demonstrates that complexing proteins are not required for the stabilisation of the neurotoxin in a formulation." @default.
- W4254303601 created "2022-05-12" @default.
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- W4254303601 date "2008-06-01" @default.
- W4254303601 modified "2023-10-14" @default.
- W4254303601 title "Xeomin® is free from complexing proteins" @default.
- W4254303601 doi "https://doi.org/10.1016/j.toxicon.2008.04.033" @default.
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