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• W4254306075 startingPage "E684" @default.
• W4254306075 abstract "To examine whether islet amyloid polypeptide (IAPP), other than through amyloid formation, may be of importance in diabetes pathogenesis, IAPP-deficient mice (IAPP − / − ) were challenged with alloxan ( day 0). Diabetes in IAPP − / − mice was more severe at day 35, indicated by greater weight loss; glucose levels were higher in alloxan-treated IAPP − / − mice, whereas insulin levels were lower, indicating a greater impairment of islet function. Accordingly, glucose levels upon intravenous glucose challenges at days 7 and 35 were consistently higher in alloxan-treated IAPP − / − mice. At day 35, insulin mRNA expression, but not β-cell mass, was lower in untreated IAPP − / − mice. Yet, upon alloxan administration, β-cell mass and numbers of β-cell-containing islets were significantly more reduced in IAPP − / − mice. Furthermore, they displayed exaggerated β-cell dysfunction, because in their remaining β-cells, insulin mRNA expression was significantly more impaired and the localization of glucose transporter-2 was perturbed. Thus the lack of IAPP has allowed exaggerated β-cell cytotoxic actions of alloxan, suggesting that there may be beneficial features of IAPP actions in situations of β-cell damage." @default.
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• W4254306075 date "2000-04-01" @default.
• W4254306075 modified "2023-10-18" @default.
• W4254306075 title "Islet amyloid polypeptide (amylin)-deficient mice develop a more severe form of alloxan-induced diabetes" @default.
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• W4254306075 doi "https://doi.org/10.1152/ajpendo.2000.278.4.e684" @default.
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